Anti‐platelet therapy: ADP receptor antagonists

The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided tha...

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Published inBritish journal of clinical pharmacology Vol. 72; no. 4; pp. 647 - 657
Main Authors Wijeyeratne, Yanushi Dullewe, Heptinstall, Stan
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2011
Blackwell Science Inc
Subjects
anti‐platelet
Blood Platelets - drug effects
cangrelor
clopidogrel
Haemostasis Themed Issue
Humans
P2Y12
platelet
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - pharmacology
prasugrel
Purinergic P2Y Receptor Antagonists - pharmacology
Thrombosis - prevention & control
ticagrelor
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Summary:The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists that are available and in development. We also consider their mode of action and ask whether there are additional mechanisms through which they exert their inhibitory effects on platelet function.
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Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms
ISSN:0306-5251
1365-2125
1365-2125
DOI:10.1111/j.1365-2125.2011.03999.x