Brain activity for tactile allodynia: a longitudinal awake rat functional magnetic resonance imaging study tracking emergence of neuropathic pain

• Published in: Pain (Amsterdam) Vol. 158; no. 3; pp. 488 - 497
• Main Authors: Chang, Pei-Ching, Centeno, Maria Virginia, Procissi, Daniel, Baria, Alex, Apkarian, A. Vania
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.03.2017
• Subjects: Analysis of Variance; Animals; Brain - diagnostic imaging; Brain Mapping; Disease Models, Animal; Hindlimb - innervation; Hyperalgesia - diagnostic imaging; Hyperalgesia - pathology; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neuralgia - diagnostic imaging; Neuralgia - physiopathology; Oxygen - blood; Rats; Rats, Sprague-Dawley; Wakefulness - physiology

Tactile allodynia, a condition in which innocuous mechanical stimuli are perceived as painful, is a common feature of chronic pain. However, how the brain reorganizes in relation to the emergence of tactile allodynia is still largely unknown. This may stem from the fact that experiments in humans ar...