Why the racing industry and equestrian disciplines need to implement population pharmacokinetics: To learn, explain, summarize, harmonize, and individualize

• Published in: Drug testing and analysis Vol. 17; no. 2; pp. 250 - 258
• Main Author: Toutain, Pierre‐Louis
• Format: Journal Article
• Language: English
• Published: England 01.02.2025
• Subjects: Animals; horses; Horses - metabolism; medication control; Models, Biological; Nonlinear Dynamics; nonlinear mixed effect model; Pharmacokinetics; population pharmacokinetics; Precision Medicine - methods; withdrawal time; medication control; nonlinear mixed effect model; withdrawal time; horses; population pharmacokinetics
• ISSN: 1942-7603; 1942-7611
• DOI: 10.1002/dta.3706

Population pharmacokinetics (POP PK) is a powerful pharmacokinetic tool, which measures quantitatively, and explains the variability in drug exposure and drug effect between individuals. POP PK uses an observational (nonexperimental) approach; it is conducted in the target population living in its normal environment (e.g., farm and race‐track). The strength of the POP PK approach lies in its greater relevance for the population studied in its different natural environments than experimental studies carried out in more or less biased laboratory conditions. In clinical settings, it is commonly necessary to restrict the number of samples per subject collected for analysis and the derived data cannot be analyzed using traditional individual data analytical methods; rather data are merged and analyzed with an appropriate statistical tool: the nonlinear mixed effect model (NLMEM). POP PK modeling is frequently used with the objective of adjusting drug dosage, and hence drug exposure, not only for the whole population but also for subgroups of animals (e.g., for a given breed, sex, and age). It can also have application at the individual subject level, in the context of precision medicine. For horses, the use of the POP PK/PD model will allow prescribers to estimate an individual Withdrawal Time for a given horse whose treatment they are supervising. Another potential field of application will be meta‐analysis of existing data to generate new knowledge on a drug or to collate and synthesize, in an objective and transparent manner, existing data; this will facilitate harmonization of screening limits at an international level. Population pharmacokinetics (POP PK) is a pharmacokinetic tool, which measures and explains the variability in drug exposure and drug effect between individuals. For prescribers, POP PK model will allow to estimate an individual Withdrawal Time for a given horse. For scientists, POP PK model will allow meta‐analysis of existing data and to generate new drug knowledge. For organisations, POP PK model will allow to objectively and impartially summarize the data available to experts, facilitating consensus when establishing international screening limits.