Desmoplastic Pattern at the Tumor Front Defines Poor-prognosis Subtypes of Colorectal Cancer

• Published in: The American journal of surgical pathology Vol. 41; no. 11; p. 1506
• Main Authors: Ueno, Hideki, Kanemitsu, Yukihide, Sekine, Shigeki, Ishiguro, Megumi, Ito, Eisaku, Hashiguchi, Yojiro, Kondo, Fukuo, Shimazaki, Hideyuki, Mochizuki, Satsuki, Kajiwara, Yoshiki, Shinto, Eiji, Yamamoto, Junji
• Format: Journal Article
• Language: English
• Published: United States 01.11.2017
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; Biopsy; Cancer-Associated Fibroblasts - chemistry; Cancer-Associated Fibroblasts - pathology; Chi-Square Distribution; Colectomy; Collagen - analysis; Colorectal Neoplasms - chemistry; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Disease-Free Survival; Extracellular Matrix - chemistry; Extracellular Matrix - pathology; Female; Humans; Hyalin - chemistry; Kaplan-Meier Estimate; Liver Neoplasms - secondary; Lung Neoplasms - secondary; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Staging; Peritoneal Neoplasms - secondary; Proportional Hazards Models; Risk Factors; Stromal Cells - chemistry; Stromal Cells - pathology; Time Factors; Tokyo; Treatment Outcome; Tumor Microenvironment; Young Adult

Although recent findings of cancer biology research indicate that prognostic power arises from genes expressed by stromal cells rather than epithelial cells, desmoplastic reaction (DR) has not been completely examined as a prognostic marker for colorectal cancer. A pathologic review of 821 stage II...