Characterization of canine filaggrin: gene structure and protein expression in dog skin

• Published in: Veterinary dermatology Vol. 24; no. 1; pp. 25 - e7
• Main Authors: Kanda, Satoko, Sasaki, Takashi, Shiohama, Aiko, Nishifuji, Koji, Amagai, Masayuki, Iwasaki, Toshiroh, Kudoh, Jun
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2013
• Subjects: Animals; Base Sequence; Blotting, Western; DNA - genetics; Dogs; Gene Expression Regulation - physiology; Genomics; Immunohistochemistry - veterinary; Intermediate Filament Proteins - genetics; Intermediate Filament Proteins - metabolism; Molecular Sequence Data; Skin - metabolism

Background –  Filaggrin (FLG) is a key protein for skin barrier formation and hydration of the stratum corneum. In humans, a strong association between FLG gene mutations and atopic dermatitis has been reported. Although similar pathogenesis and clinical manifestation have been argued in canine atop...