Cell response of Escherichia coli to cisplatin-induced stress

• Published in: Proteomics (Weinheim) Vol. 11; no. 21; pp. 4174 - 4188
• Main Authors: Stefanopoulou, Maria, Kokoschka, Malte, Sheldrick, William S., Wolters, Dirk A.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.11.2011; WILEY‐VCH Verlag; Wiley-VCH; Wiley Subscription Services, Inc
• Subjects: Aconitate hydratase; Amino Acid Sequence; Amino acids; Analytical, structural and metabolic biochemistry; Antineoplastic Agents - pharmacology; Antitumor agents; Apoptosis; Biological and medical sciences; Chaperonins; Cisplatin; Cisplatin - pharmacology; Cytostatic cell response; E coli; Energy metabolism; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; Escherichia coli - growth & development; Escherichia coli - metabolism; Escherichia coli Proteins - chemistry; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Bacterial - drug effects; Glycolysis; Medical research; Microbiology; Miscellaneous; Mode of action; Models, Molecular; Molecular Sequence Data; nucleoside triphosphates; Nucleoside-triphosphate pyrophosphatase; Phosphopyruvate hydratase; Protein biosynthesis; Protein synthesis; Proteins; proteomics; Pyrophosphatases - chemistry; Pyrophosphatases - genetics; Pyrophosphatases - metabolism; ribosomal protein S1; Side effects; Stress; Microbiology; Escherichia coli; Proteomics; Bacteria; Cisplatin; Stress; Cytostatic cell response; Enterobacteriaceae

Cisplatin is undoubtedly one of the most common and successful anticancer drugs worldwide. Though its DNA‐based mechanism of action is well established, the contribution of the proteome to this process remains unclear. The possible impact of particular Escherichia coli proteins on the cytostatic act...