Genetic Characterization of Primary Mediastinal B-Cell Lymphoma: Pathogenesis and Patient Outcomes

• Published in: Journal of clinical oncology Vol. 42; no. 4; pp. 452 - 466
• Main Authors: Noerenberg, Daniel, Briest, Franziska, Hennch, Cornelius, Yoshida, Kenichi, Hablesreiter, Raphael, Takeuchi, Yasuhide, Ueno, Hiroo, Staiger, Annette M., Ziepert, Marita, Asmar, Fazila, Locher, Benjamin N., Toth, Erika, Weber, Thomas, Amini, Rose-Marie, Klapper, Wolfram, Bouzani, Maria, Poeschel, Viola, Rosenwald, Andreas, Held, Gerhard, Campo, Elías, Ishaque, Naveed, Stamatopoulos, Kostas, Kanellis, George, Anagnostopoulos, Ioannis, Bullinger, Lars, Goldschmidt, Neta, Zinzani, Pier Luigi, Bödör, Csaba, Rosenquist, Richard, Vassilakopoulos, Theodoros P., Ott, German, Ogawa, Seishi, Damm, Frederik
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.02.2024

PURPOSEPrimary mediastinal large B-cell lymphoma (PMBCL) is a rare aggressive lymphoma predominantly affecting young female patients. Large-scale genomic investigations and genetic markers for risk stratification are lacking.PATIENTS AND METHODSTo elucidate the full spectrum of genomic alterations,...