The widely conserved Era G‐protein contains an RNA‐binding domain required for Era function in vivo

• Published in: Molecular microbiology Vol. 33; no. 6; pp. 1118 - 1131
• Main Authors: Johnstone, Brian H., Handler, Aaron A., Chao, Diana K., Nguyen, Vi, Smith, Michael, Ryu, Seung Y., Simons, Elizabeth L., Anderson, Paul E., Simons, Robert W.
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.09.1999; Blackwell Publishing Ltd
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Base Sequence; Binding Sites - genetics; Cell Division - genetics; Chromosomes, Bacterial - genetics; Conserved Sequence; DNA Primers - genetics; Escherichia coli; Escherichia coli - cytology; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli Proteins; GTP-Binding Proteins - genetics; GTP-Binding Proteins - metabolism; Molecular Sequence Data; Mutation; Protein Binding; Ribonucleoproteins - metabolism; RNA - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Sequence Homology, Amino Acid

Era is a small G‐protein widely conserved in eubacteria and eukaryotes. Although essential for bacterial growth and implicated in diverse cellular processes, its actual function remains unclear. Several lines of evidence suggest that Era may be involved in some aspect of RNA biology. The GTPase doma...