Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer

• Published in: Cochrane database of systematic reviews Vol. 8; p. CD010511
• Main Authors: Vellayappan, Balamurugan A, Soon, Yu Yang, Ku, Geoffrey Y, Leong, Cheng Nang, Lu, Jiade J, Tey, Jeremy Cs
• Format: Journal Article
• Language: English
• Published: England 22.08.2017
• Subjects: Carcinoma - mortality; Carcinoma - pathology; Carcinoma - surgery; Carcinoma - therapy; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Carcinoma, Squamous Cell - therapy; Chemoradiotherapy - adverse effects; Chemoradiotherapy - mortality; Cisplatin; Combined Modality Therapy - adverse effects; Combined Modality Therapy - methods; Combined Modality Therapy - mortality; Deglutition Disorders - therapy; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophageal Neoplasms - therapy; Esophagectomy - mortality; Fluorouracil - administration & dosage; Humans; Neoplasm Recurrence, Local; Quality of Life; Randomized Controlled Trials as Topic

Please see Appendix 4 for a glossary of terms.The outcome of patients with esophageal cancer is generally poor. Although multimodal therapy is standard, there is conflicting evidence regarding the addition of esophagectomy to chemoradiotherapy. To compare the effectiveness and safety of chemoradioth...