Convenient and Efficient Synthesis of Functionalized 2-Sulfenylindoles

• Published in: Materials Vol. 13; no. 20; p. 4492
• Main Authors: Doroszuk, Justyna, Musiejuk, Mateusz, Jędrzejewski, Bartosz, Walczak, Juliusz, Witt, Dariusz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.10.2020; MDPI
• Subjects: Carbon; Chromatography; Communication; indoles; Reagents; Sodium; sulfenylation; sulfenylindoles; sulfides; thiotosylates; Germany; thiotosylates; indoles; sulfenylation; sulfenylindoles; sulfides

A simple, efficient, and practical sulfenylation at the C2 position of -tosylindoles under mild conditions was developed. The designed transformation is based on the reaction of -tosylindoles with BuLi and -alkyl, and -aryl phosphorodithioates or thiotosylates to produce 2-sulfenylindoles in moderat...