Regulation of Fas Alternative Splicing by Antagonistic Effects of TIA-1 and PTB on Exon Definition

• Published in: Molecular cell Vol. 19; no. 4; pp. 475 - 484
• Main Authors: Izquierdo, José María, Majós, Nuria, Bonnal, Sophie, Martínez, Concepción, Castelo, Robert, Guigó, Roderic, Bilbao, Daniel, Valcárcel, Juan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.08.2005
• Subjects: Alternative Splicing; Apoptosis; Base Sequence; Exons; fas Receptor - genetics; fas Receptor - metabolism; Gene Expression Regulation; Gene Silencing; HeLa Cells; Humans; Models, Molecular; Molecular Sequence Data; Nuclear Proteins - metabolism; Poly(A)-Binding Proteins; Polypyrimidine Tract-Binding Protein - metabolism; Polypyrimidine Tract-Binding Protein - pharmacology; Proteins - metabolism; Proteins - pharmacology; Ribonucleoproteins - metabolism; RNA-Binding Proteins; Splicing Factor U2AF; T-Cell Intracellular Antigen-1

Fas exon 6 can be included or skipped to generate mRNAs encoding, respectively, a membrane bound form of the receptor that promotes apoptosis or a soluble isoform that prevents programmed cell death. We report that the apoptosis-inducing protein TIA-1 promotes U1 snRNP binding to the 5′ splice site...