Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice

• Published in: Journal of developmental biology Vol. 6; no. 4; p. 27
• Main Authors: Sen, Rwik, Pezoa, Sofia A, Carpio Shull, Lomeli, Hernandez-Lagunas, Laura, Niswander, Lee A, Artinger, Kristin Bruk
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.11.2018; MDPI
• Subjects: Acetylation; Acetyltransferase; Bones; Cartilage; Cbfa-1 protein; Cell differentiation; Central nervous system; cranial neural crest cells; Craniofacial growth; craniofacial skeleton; CRISPR; Danio rerio; DNA methylation; Embryogenesis; Embryos; Enzymes; Epigenetics; GCN5; Gene expression; Genomes; Heart; histone H3K9 acetylation; Histones; Lysine; Mutagenesis; Mutation; Neural crest; Pattern formation; PCAF; RNA polymerase; Skeleton; Skull; Sox9 protein; Vertebrates; Zebrafish; craniofacial skeleton; GCN5; cranial neural crest cells; PCAF; histone H3K9 acetylation

Cranial neural crest cells undergo cellular growth, patterning, and differentiation within the branchial arches to form cartilage and bone, resulting in a precise pattern of skeletal elements forming the craniofacial skeleton. However, it is unclear how cranial neural crest cells are regulated to gi...