Behavioral, Virologic, and Immunologic Factors Associated With Acquisition and Severity of Primary Epstein-Barr Virus Infection in University Students

• Published in: The Journal of infectious diseases Vol. 207; no. 1; pp. 80 - 88
• Main Authors: Balfour, Henry H., Odumade, Oludare A., Schmeling, David O., Mullan, Beth D., Ed, Julie A., Knight, Jennifer A., Vezina, Heather E., Thomas, William, Hogquist, Kristin A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2013
• Subjects: Antibodies; Antibodies, Viral - blood; Biological and medical sciences; Blood; CD8-Positive T-Lymphocytes - immunology; Cytokines - blood; Diseases; DNA, Viral - blood; Epstein Barr virus infections; Epstein-Barr virus; Female; Fundamental and applied biological sciences. Psychology; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - immunology; Herpesvirus 4, Human - isolation & purification; Humans; Incidence; Infections; Infectious diseases; Infectious Mononucleosis - epidemiology; Infectious Mononucleosis - immunology; Infectious Mononucleosis - transmission; Infectious Mononucleosis - virology; Kaplan-Meier Estimate; Killer Cells, Natural - immunology; Lymphocytosis - immunology; Major and Brief Reports; Male; Medical sciences; Microbiology; Minnesota - epidemiology; Miscellaneous; Natural killer cells; Prospective Studies; Risk Factors; Sentinel Surveillance; Severity of Illness Index; Students; Symptomatology; T lymphocytes; Universities; Viral Load; Viremia; Virology; Viruses; Young Adult; Minnesota; Gammaherpesvirinae; Virus; Infection; Primary infection; Herpesviridae; Epstein Barr virus; Student

Background. University students were studied prospectively to determine the incidence of and risk factors for acquisition of primary Epstein-Barr virus (EBV) infection and the virologic and immune correlates of disease severity. Methods. EBV antibody-negative freshmen participated in monthly surveil...