Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis

• Published in: The Journal of immunology (1950) Vol. 181; no. 11; pp. 7480 - 7488
• Main Authors: Murugaiyan, Gopal, Mittal, Akanksha, Weiner, Howard L
• Format: Journal Article
• Language: English
• Published: England Am Assoc Immnol 01.12.2008
• Subjects: Animals; Antibodies - pharmacology; Cell Differentiation - immunology; Cells, Cultured; Dendritic Cells - immunology; Encephalomyelitis, Autoimmune, Experimental - genetics; Encephalomyelitis, Autoimmune, Experimental - immunology; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Humans; Hyaluronan Receptors - genetics; Hyaluronan Receptors - immunology; Integrin alphaV - genetics; Integrin alphaV - immunology; Integrin beta3 - genetics; Integrin beta3 - immunology; Interferon-gamma - genetics; Interferon-gamma - immunology; Interleukin-10 - genetics; Interleukin-10 - immunology; Interleukin-17 - genetics; Interleukin-17 - immunology; Mice; Mice, Knockout; Multiple Sclerosis - genetics; Multiple Sclerosis - immunology; Osteopontin - antagonists & inhibitors; Osteopontin - genetics; Osteopontin - immunology; Th1 Cells - immunology

Osteopontin (Opn) is a broadly expressed pleiotropic cytokine, and has been shown to play an important role in various autoimmune diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). It is reported that Opn exacerbates EAE by skewing T cel...