Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo

• Published in: Marine drugs Vol. 16; no. 12; p. 473
• Main Authors: Zhang, Shan-Shan, Han, Li-Wen, Shi, Yong-Ping, Li, Xiao-Bin, Zhang, Xuan-Ming, Hou, Hai-Rong, Lin, Hou-Wen, Liu, Ke-Chun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.11.2018; MDPI
• Subjects: ACE-inhibitory activity; Amino acids; Angiotensin; anti-diabetic activity; Antidiabetics; antioxidant activity; Antioxidants; Apoptosis; Bio-assays; Bioassays; Biocompatibility; Biological activity; Diabetes; Diabetes mellitus; Digestive system; Freshwater fishes; Gastrointestinal tract; Hydrophobicity; Liquid chromatography; Low molecular weights; Mass spectrometry; Mass spectroscopy; Meat; Molecular docking; Molecular weight; Mollusks; multi-functional peptides; Neptunea; Neptunea arthritica cumingii; Peptides; Peptidyl-dipeptidase A; Protected species; Reactive oxygen species; Scavenging; Skin; Stability; Stability analysis; Synthetic peptides; Thermal simulation; Thermal stress; Toxicity; Zebrafish; Neptunea arthritica cumingii; ACE-inhibitory activity; anti-diabetic activity; antioxidant activity; multi-functional peptides

Neptunea arthritica cumingii (Nac) is a marine snail with high nutritional and commercial value; however, little is known about its active peptides. In this study, two multi-functional peptides, YSQLENEFDR (Tyr-Ser-Gln-Leu-Glu-Asn-Glu-Phe-Asp-Arg) and YIAEDAER (Tyr-Ile-Ala-Glu-Asp-Ala-Glu-Arg), were...