Tumor-Penetrating Microparticles for Intraperitoneal Therapy of Ovarian Cancer

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 327; no. 3; pp. 673 - 682
• Main Authors: Lu, Ze, Tsai, Max, Lu, Dan, Wang, Jie, Wientjes, M. Guillaume, Au, Jessie L.-S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2008; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - toxicity; Delayed-Action Preparations; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug Delivery Systems - methods; Female; Humans; Injections, Intraperitoneal; Kinetics; Mice; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Paclitaxel - administration & dosage; Paclitaxel - toxicity; Treatment Outcome; Xenograft Model Antitumor Assays

Intraperitoneal chemotherapy prolongs survival of ovarian cancer patients, but its utility is limited by treatment-related complications and inadequate drug penetration in larger tumors. Previous intraperitoneal therapy used the paclitaxel/Cremophor EL (polyethoxylated castor oil) formulation design...