Macrophage activation by bacterial cell walls and related synthetic compounds

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Published inInfection and Immunity Vol. 25; no. 1; pp. 48 - 53
Main Authors Takada, H, Tsujimoto, M, Kato, K, Kotani, S, Kusumoto, S, Inage, M, Shiba, T, Yano, I, Kawata, S, Yokogawa, K
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.07.1979
Subjects
Acetylmuramyl-Alanyl-Isoglutamine - immunology
Animals
Bacteria - ultrastructure
Cell Wall - immunology
Glucosamine - metabolism
Glycopeptides - immunology
Guinea Pigs
Lactobacillus - ultrastructure
Macrophages - immunology
Macrophages - metabolism
Mycobacterium - ultrastructure
Nocardia - ultrastructure
Streptomyces - ultrastructure
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Abstract Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
AbstractList Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls and synthetic muramyl dipeptides was studied in terms of stimulation of [14C] glucosamine incorporation. All test bacterial cell wall preparations significantly increased a [14C]glucosamine uptake by the macrophages. Some of the water-soluble M-1 enzyme digests also exerted stimulating effects on macrophages, although the activity of the digests was found to be weaker than those of original cell walls. Furthermore, an adjuvant-active synthetic MurNAc-L-Ala-D-isoGln (MDP) showed a weak but significant activity, whereas an adjuvant-inactive analog, MurNAc-L-Ala-L-iso-Gln, did not show a significant activity, at least with the dose of 100 microgram. Additional studies with 6-O-acyl derivatives of MDP revealed that 6-O-(2-tetradecylhexadecanoyl)-MDP and 6-O-(3-hydroxy-2-tetradecyl-octadecanoyl)-MDP exhibit stronger macrophage-stimulating effects than MDP. It can be concluded from the above findings that MDP is the essential structure responsible for stimulating the activity of cell walls on guinea pig peritoneal macrophages, but it requires a particle state, which results from an additive character of lipophilicity, to exert the activity fully and effectively.
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Author K Yokogawa
H Takada
M Inage
M Tsujimoto
S Kusumoto
K Kato
S Kawata
I Yano
T Shiba
S Kotani
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Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls...
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StartPage 48
SubjectTerms Acetylmuramyl-Alanyl-Isoglutamine - immunology
Animals
Bacteria - ultrastructure
Cell Wall - immunology
Glucosamine - metabolism
Glycopeptides - immunology
Guinea Pigs
Lactobacillus - ultrastructure
Macrophages - immunology
Macrophages - metabolism
Mycobacterium - ultrastructure
Nocardia - ultrastructure
Streptomyces - ultrastructure
Title Macrophage activation by bacterial cell walls and related synthetic compounds
URI http://iai.asm.org/content/25/1/48.abstract
https://www.ncbi.nlm.nih.gov/pubmed/478648
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Volume 25
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