Anti-BACE1 and Antimicrobial Activities of Steroidal Compounds Isolated from Marine Urechis unicinctus

• Published in: Marine drugs Vol. 16; no. 3; p. 94
• Main Authors: Zhu, Yong-Zhe, Liu, Jing-Wen, Wang, Xue, Jeong, In-Hong, Ahn, Young-Joon, Zhang, Chuan-Jie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.03.2018; MDPI
• Subjects: Alzheimer Disease - drug therapy; Alzheimer's disease; Amyloid Precursor Protein Secretases - antagonists & inhibitors; Amyloid Precursor Protein Secretases - metabolism; Animals; Anti-Infective Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Aquatic Organisms - chemistry; Aspartic Acid Endopeptidases - antagonists & inhibitors; BACE1; Bacteria - drug effects; Bio-assays; Bioactive compounds; bioassay-directed isolation; Bioassays; Biological Products - chemistry; Biological Products - pharmacology; Data processing; Disease resistance; Drug development; E coli; Enzymes; Ethanol; Fractionation; Humans; marine bioactive; Mass spectrometry; Mass spectroscopy; Medical treatment; Medicine; Minimum inhibitory concentration; NMR; Nuclear magnetic resonance; Polychaeta - chemistry; Salmonella; Steroids - chemistry; Steroids - pharmacology; Urechis unicinctus; β-Site APP-cleaving enzyme 1; BACE1; antimicrobial activity; Alzheimer’s disease; bioassay-directed isolation; Urechis unicinctus; marine bioactive

The human β-site amyloid cleaving enzyme (BACE1) has been considered as an effective drug target for treatment of Alzheimer's disease (AD). In this study, , which is a Far East specialty food known as innkeeper worm, ethanol extract was studied by bioassay-directed fractionation and isolation t...