Enantioselective intramolecular C–H amination of aliphatic azides by dual ruthenium and phosphine catalysis

• Published in: Chemical science (Cambridge) Vol. 10; no. 11; pp. 3202 - 3207
• Main Authors: Qin, Jie, Zhou, Zijun, Cui, Tianjiao, Hemming, Marcel, Meggers, Eric
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.03.2019; Royal Society of Chemistry
• Subjects: Aliphatic compounds; Amines; Aromatic compounds; Azides (organic); Catalysis; Chemistry; Chemistry, Multidisciplinary; Coordination compounds; Enantiomers; Physical Sciences; Ruthenium compounds; Science & Technology; PHOSPHORYL AZIDES; FUNCTIONALIZATION; NITRENE TRANSFER; PYRROLIDINE; BOND AMINATION; AZIRIDINATION; COMPLEXES; ARYL AZIDES; C(SP)-H; ALKYL AZIDES

The catalytic enantioselective intramolecular C(sp 3 )-H amination of aliphatic azides represents an efficient method for constructing chiral saturated cyclic amines which constitute a prominent structural motif in bioactive compounds. We report a dual catalytic system involving a chiral-at-metal bi...