A Novel SimpleDrop Chip for 3D Spheroid Formation and Anti-Cancer Drug Assay

• Published in: Micromachines (Basel) Vol. 12; no. 6; p. 681
• Main Authors: Liu, Xiaoli, Lin, Huichao, Song, Jiaao, Zhang, Taiyi, Wang, Xiaoying, Huang, Xiaowen, Zheng, Chengyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.06.2021; MDPI
• Subjects: 3D cell spheres; Apoptosis; Assaying; cancer; Cancer therapies; Cell culture; Cell growth; drug assay; Drugs; Flasks; Medical research; Methotrexate; micro-hole culture chip; Micropatterning; Screening; Shear forces; Signal transduction; Spheres; Spheroids; Tissue engineering; United States > US; cancer; 3D cell spheres; cell culture; drug assay; micro-hole culture chip

Cell culture is important for the rapid screening of anti-cancer drug candidates, attracting intense interest. Traditional 2D cell culture has been widely utilized in cancer biological research. However, 3D cellular spheroids are able to recapitulate the in vivo microenvironment of tissues or tumors...