Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 17; no. 2; pp. 226 - 234
• Main Authors: Ghoshal, Ujjala, Tripathi, Shweta, Kumar, Sushil, Mittal, Balraj, Chourasia, Dipti, Kumari, Niraj, Krishnani, Narendra, Ghoshal, Uday C.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.04.2014; Springer Nature B.V
• Subjects: Abdominal Surgery; Biomarkers, Tumor - genetics; Cancer Research; Case-Control Studies; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A2 - genetics; Female; Follow-Up Studies; Gastric cancer; Gastroenterology; Genetic Predisposition to Disease; Genotype; Helicobacter Infections - genetics; Helicobacter Infections - pathology; Helicobacter Infections - virology; Helicobacter pylori; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Oncology; Original Article; Peptic Ulcer - genetics; Peptic Ulcer - pathology; Peptic Ulcer - virology; Polymorphism, Genetic - genetics; Prognosis; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Stomach Neoplasms - virology; Surgical Oncology; Peptic ulcer; Gastric cancer; Functional dyspepsia; Genetic polymorphism

Background Activity of cytochrome P450 (CYP), a polymorphic carcinogen-activating enzyme, is exaggerated following Helicobacter pylori infection. We studied the role of CYP2E1, CYP1A2 (rs762551), and CYP1A1 (rs4646903 ) polymorphisms in association with H. pylori infection in gastric carcinogenesis....