Sensitivity of [11C]ORM-13070 to increased extracellular noradrenaline in the CNS – a PET study in human subjects

• Published in: Psychopharmacology Vol. 232; no. 21-22; pp. 4169 - 4178
• Main Authors: Lehto, Jussi, Johansson, Jarkko, Vuorilehto, Lauri, Luoto, Pauliina, Arponen, Eveliina, Scheinin, Harry, Rouru, Juha, Scheinin, Mika
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2015; Springer; Springer Nature B.V
• Subjects: Adult; Analysis; Biomedical and Life Sciences; Biomedicine; Brain; Caudate Nucleus - diagnostic imaging; Caudate Nucleus - metabolism; Humans; Male; Neuropsychology; Neurosciences; Neurotransmitters; Norepinephrine - metabolism; Original Investigation; PET imaging; Pharmacology/Toxicology; Positron-Emission Tomography - methods; Psychiatry; Psychopharmacology; Putamen - diagnostic imaging; Putamen - metabolism; Radiopharmaceuticals - metabolism; Tomography; Tracers (Biology); Young Adult; Finland; Striatum; α; Ketamine; Atomoxetine; Carbon-11; Noradrenaline; Adrenoceptor; PET; α2C-Adrenoceptor

Rationale No validated methods have been available for studying brain noradrenergic neurotransmission in vivo in humans. Positron emission tomography (PET) radiotracers are widely used in clinical drug development targeted to brain receptors and can also in some cases be employed to monitor extracel...