A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response

• Published in: The Journal of infectious diseases Vol. 209; no. 12; pp. 1860 - 1869
• Main Authors: Talaat, Kawsar R., Luke, Catherine J., Khurana, Surender, Manischewitz, Jody, King, Lisa R., McMahon, Bridget A., Karron, Ruth A., Lewis, Kristen D. C., Qin, Jing, Follmann, Dean A., Golding, Hana, Neuzil, Kathleen M., Subbarao, Kanta
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.06.2014
• Series: Editor's choice
• Subjects: Adult; Antibodies; Antibodies, Viral - blood; Antibody Affinity; Antibody Formation - immunology; Antibody response; Applied microbiology; Attenuated vaccines; Biological and medical sciences; Cross Reactions; Dosage; Female; Fundamental and applied biological sciences. Psychology; H5N1 subtype influenza A virus; Healthy Volunteers; Hemagglutination Inhibition Tests; Humans; Inactivated vaccines; Infectious diseases; Influenza A virus; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H7N3 Subtype - immunology; Influenza vaccines; Influenza Vaccines - immunology; Influenza Vaccines - therapeutic use; Major and Brief Reports; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Pandemics; Transcriptional regulatory elements; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - immunology; Vaccines, Attenuated - therapeutic use; Virology; VIRUSES; Young Adult; Virus; Infection; Influenzavirus A; Immune response; Influenza A virus; Viral disease; Orthomyxoviridae; Influenza A; Vaccine; Attenuated strain; Humoral immunity; live attenuated; H5N1; vaccine; avian influenza

Background. Highly pathogenic avian influenza A(H5N1) causes severe infections in humans. We generated 2 influenza A(H5N1) live attenuated influenza vaccines for pandemic use (pLAIVs), but they failed to elicit a primary immune response. Our objective was to determine whether the vaccines primed or...