Black Sorghum Phenolic Extract Modulates Platelet Activation and Platelet Microparticle Release

• Published in: Nutrients Vol. 12; no. 6; p. 1760
• Main Authors: Ed Nignpense, Borkwei, Chinkwo, Kenneth A, Blanchard, Christopher L, Santhakumar, Abishek B
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.06.2020; MDPI
• Subjects: Activation; Adenine; Adenosine diphosphate; Anticoagulants; Antioxidants; Antioxidants - pharmacology; Atherosclerosis; Biomarkers; black sorghum; Blood clots; Blood platelets; Blood Platelets - drug effects; Blood Platelets - metabolism; Cardiovascular diseases; Cell-Derived Microparticles - drug effects; Collagen; Cytotoxicity; Degranulation; Evaluation; Flow Cytometry; Gene expression; Hematology; Humans; Medical screening; Oxidative stress; Oxidative Stress - drug effects; P-selectin; PAC1 protein; Pathogenesis; Phenolic compounds; Phenols; Plant Extracts - chemistry; Plant Extracts - pharmacology; Platelet Activation - drug effects; Platelet aggregation; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - chemistry; Platelet Aggregation Inhibitors - pharmacology; Platelet Function Tests; platelet microparticles; platelets; Polyphenols; Polyphenols - pharmacology; Quality control; Questionnaires; Signal transduction; Size distribution; Sodium; Sorghum; Sorghum - chemistry; Thrombosis; Australia; atherosclerosis; black sorghum; polyphenols; platelet microparticles; platelets

Platelet hyper-activation and platelet microparticles (PMPs) play a key role in the pathogenesis of cardiovascular diseases. Dietary polyphenols are believed to mimic antiplatelet agents by blunting platelet activation receptors via its antioxidant phenomenon. However, there is limited information o...