Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

• Published in: The Journal of infectious diseases Vol. 206; no. 2; pp. 275 - 282
• Main Authors: Valcour, Victor, Chalermchai, Thep, Sailasuta, Napapon, Marovich, Mary, Lerdlum, Sukalaya, Suttichom, Duanghathai, Suwanwela, Nijasri C., Jagodzinski, Linda, Michael, Nelson, Spudich, Serena, van Griensven, Frits, de Souza, Mark, Kim, Jerome, Ananworanich, Jintanat
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.07.2012
• Subjects: Acute Disease; Adult; AIDS; Biological and medical sciences; Blood plasma; Central nervous system; Central Nervous System Infections - cerebrospinal fluid; Central Nervous System Infections - pathology; Central Nervous System Infections - virology; Cerebrospinal fluid; Female; Fundamental and applied biological sciences. Psychology; HIV; HIV 1; HIV infections; HIV Infections - cerebrospinal fluid; HIV Infections - complications; HIV Infections - virology; HIV/AIDS; Human immunodeficiency virus; Human viral diseases; Humans; Infections; Infectious diseases; Inflammation; Inflammation - cerebrospinal fluid; Inflammation - virology; Magnetic Resonance Imaging; Major and Brief Reports; Male; Medical sciences; Microbiology; Middle Aged; RNA; RNA, Viral - cerebrospinal fluid; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Young Adult; Infection; Immunopathology; Viral disease; Acute; Central nervous system; AIDS; Inflammation; Immune deficiency

Background. Understanding the earliest central nervous system (CNS) events during human immunodeficiency virus (HIV) infection is crucial to knowledge of neuropathogenesis, but these have not previously been described in humans. Methods. Twenty individuals who had acute HIV infection (Fiebig stages...