Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS

Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Methods. Patients with early (first 48 hrs) SS ( n = 2...

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Published inBioMed research international Vol. 2014; no. 2014; pp. 1 - 8
Main Authors Nanas, S., Briassoulis, George, Routsi, C., Tsagarakis, S., Botoula, E., Psarra, K., Goukos, D., Briassouli, Efrossini, Apostolou, Kleovoulos, Vardas, K., Magira, E.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2014
Subjects
Adrenocorticotropic Hormone - blood
Adult
Case-Control Studies
Female
HSP72 Heat-Shock Proteins - blood
HSP90 Heat-Shock Proteins - blood
Humans
Hydrocortisone - blood
Male
Middle Aged
Prolactin - blood
Sepsis - blood
Sepsis - epidemiology
Stress, Physiological
Systemic Inflammatory Response Syndrome - blood
Systemic Inflammatory Response Syndrome - epidemiology
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Abstract Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Methods. Patients with early (first 48 hrs) SS ( n = 29 ) or SIRS ( n = 29 ) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H ( P < 0.003 ). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H ( P < 0.005 ). SS monocytes expressed lower iHSP72 MFI levels compared to H ( P = 0.03 ). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate ( P < 0.05 ). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
AbstractList Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Methods . Patients with early (first 48 hrs) SS ( n = 29) or SIRS ( n = 29) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry. Results . Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H ( P < 0.003). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H ( P < 0.005). SS monocytes expressed lower iHSP72 MFI levels compared to H ( P = 0.03). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate ( P < 0.05). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion . Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Patients with early (first 48 hrs) SS (n = 29) or SIRS (n = 29) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P < 0.003). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P < 0.005). SS monocytes expressed lower iHSP72 MFI levels compared to H (P = 0.03). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P < 0.05). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Methods. Patients with early (first 48 hrs) SS ( n = 29 ) or SIRS ( n = 29 ) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry. Results. Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H ( P < 0.003 ). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H ( P < 0.005 ). SS monocytes expressed lower iHSP72 MFI levels compared to H ( P = 0.03 ). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate ( P < 0.05 ). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion. Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Methods . Patients with early (first 48 hrs) SS ( n=29 ) or SIRS ( n=29 ) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90 alpha , eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90 alpha ) were measured using 4-colour flow-cytometry. Results . Prolactin, cortisol, and eHSP90 alpha levels were significantly increased in SS patients compared to SIRS and H ( P<0.003 ). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H ( P<0.005 ). SS monocytes expressed lower iHSP72 MFI levels compared to H ( P=0.03 ). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90 alpha , IL-6, and lactate ( P<0.05 ). In SS and SIRS eHSP90 alpha was related with eHSP72, IL-6, and IL-10. Conclusion . Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90 alpha , monocytes suppress iHSP72, and plasma eHSP72 increases.
Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H). Methods . Patients with early (first 48 hrs) SS ( n = 29 ) or SIRS ( n = 29 ) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry. Results . Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H ( P < 0.003 ). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H ( P < 0.005 ). SS monocytes expressed lower iHSP72 MFI levels compared to H ( P = 0.03 ). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate ( P < 0.05 ). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10. Conclusion . Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H).OBJECTIVETo evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects (H).Patients with early (first 48 hrs) SS (n = 29) or SIRS (n = 29) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry.METHODSPatients with early (first 48 hrs) SS (n = 29) or SIRS (n = 29) admitted to a university ICU and 16 H were enrolled in the study. Serum prolactin, cortisol, and plasma ACTH were determined using immunoassay analyzers. ELISA was used to evaluate extracellular HSPs (eHSP90α, eHSP72) and interleukins. Mean fluorescence intensity (MFI) values for intracellular HSPs (iHSP72, iHSP90α) were measured using 4-colour flow-cytometry.Prolactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P < 0.003). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P < 0.005). SS monocytes expressed lower iHSP72 MFI levels compared to H (P = 0.03). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P < 0.05). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10.RESULTSProlactin, cortisol, and eHSP90α levels were significantly increased in SS patients compared to SIRS and H (P < 0.003). ACTH and eHSP72 were significantly higher in SS and SIRS compared to H (P < 0.005). SS monocytes expressed lower iHSP72 MFI levels compared to H (P = 0.03). Prolactin was related with SAPS III and APACHE II scores and cortisol with eHSP90α, IL-6, and lactate (P < 0.05). In SS and SIRS eHSP90α was related with eHSP72, IL-6, and IL-10.Prolactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.CONCLUSIONProlactin, apart from cortisol, may have a role in the acute stress response in severe sepsis. In this early-onset inflammatory process, cortisol relates to eHSP90α, monocytes suppress iHSP72, and plasma eHSP72 increases.
Author Goukos, D.
Magira, E.
Briassouli, Efrossini
Nanas, S.
Psarra, K.
Vardas, K.
Routsi, C.
Apostolou, Kleovoulos
Briassoulis, George
Tsagarakis, S.
Botoula, E.
AuthorAffiliation 4 Department of Endocrinology and Diabetes, Evangelismos Hospital, Ipsilantou 45, 10676 Athens, Greece
2 1st Department of Propaedeutic Internal Medicine, Laiko University General Hospital, University of Athens, 17 Agiou Thoma, 115 27 Athens, Greece
5 Pediatric Intensive Care Unit, School of Health Sciences, University Hospital, University of Crete, 71110 Heraklion, Greece
1 First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, Ipsilantou 45, 10676 Athens, Greece
3 Immunology-Histocompatibility Department, Evangelismos Hospital, Ipsilantou 45, 10676 Athens, Greece
AuthorAffiliation_xml – name: 1 First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, Ipsilantou 45, 10676 Athens, Greece
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Snippet Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock...
Objective. To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock...
To evaluate the early heat shock protein (HSP) and hormonal stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or...
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SubjectTerms Adrenocorticotropic Hormone - blood
Adult
Case-Control Studies
Female
HSP72 Heat-Shock Proteins - blood
HSP90 Heat-Shock Proteins - blood
Humans
Hydrocortisone - blood
Male
Middle Aged
Prolactin - blood
Sepsis - blood
Sepsis - epidemiology
Stress, Physiological
Systemic Inflammatory Response Syndrome - blood
Systemic Inflammatory Response Syndrome - epidemiology
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Title Early Response Roles for Prolactin Cortisol and Circulating and Cellular Levels of Heat Shock Proteins 72 and 90α in Severe Sepsis and SIRS
URI https://search.emarefa.net/detail/BIM-1034567
https://dx.doi.org/10.1155/2014/803561
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Volume 2014
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