Herring Milt and Herring Milt Protein Hydrolysate Are Equally Effective in Improving Insulin Sensitivity and Pancreatic Beta-Cell Function in Diet-Induced Obese- and Insulin-Resistant Mice

• Published in: Marine drugs Vol. 18; no. 12; p. 635
• Main Authors: Wang, Yanwen, Nair, Sandhya, Gagnon, Jacques
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.12.2020; MDPI
• Subjects: Amino acids; Animal Feed; Animals; Beta cells; Biomarkers; Biomarkers - blood; Blood; Blood glucose; Blood Glucose - metabolism; Body weight; Body weight gain; Carbohydrates; Carnitine; Casein; Cholesterol; Control; Diabetes; Diabetes mellitus; Diet; Diet, High-Fat; Disease Models, Animal; Energy Intake; Equivalence; Fatty acids; Fatty Acids, Nonesterified - blood; Fish Proteins, Dietary - administration & dosage; Fish Proteins, Dietary - metabolism; Food; Glucose; Glucose tolerance; Glycemic Control; herring milt dry powder; herring milt protein hydrolysate; High density lipoprotein; High fat diet; HOMA-IR; HOMA-β; Homeostasis; Insulin; Insulin - blood; Insulin Resistance; Insulin-Secreting Cells - metabolism; Leptin; Leptin - blood; Lipids; Low fat diet; Male; Metabolism; Mice, Inbred C57BL; Nutrient deficiency; Nutrients; Obesity; Obesity - diet therapy; Obesity - metabolism; Obesity - physiopathology; Pancreas; Peptides; Phenotypes; Protein Hydrolysates - administration & dosage; Protein Hydrolysates - metabolism; Proteins; Sensitivity; Weight Loss; HOMA-IR; blood glucose; herring milt dry powder; QUICKI; high-fat diet; oral glucose tolerance; HOMA-β; herring milt protein hydrolysate; insulin resistance; mice

Although genetic predisposition influences the onset and progression of insulin resistance and diabetes, dietary nutrients are critical. In general, protein is beneficial relative to carbohydrate and fat but dependent on protein source. Our recent study demonstrated that 70% replacement of dietary c...