Identification of a Human SCARB2 Region That Is Important for Enterovirus 71 Binding and Infection
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| Published in | Journal of Virology Vol. 85; no. 10; pp. 4937 - 4946 |
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We previously identified human scavenger receptor class B, member 2 (SCARB2), as a cellular receptor for enterovirus 71 (EV71). Expression of human SCARB2 (hSCARB2) permitted mouse L929 cells to efficiently bind to virions and to produce both viral proteins and progeny viruses upon EV71 infection. Mouse Scarb2 (mScarb2) exhibited 85.8% amino acid identity and 99.9% similarity to hSCARB2. The expression of mScarb2 in L929 cells conferred partial susceptibility. Very few virions bound to mScarb2-expressing cells. The viral titer in L929 cells expressing mScarb2 was approximately 40- to 100-fold lower than that in L929 cells expressing hSCARB2. Using hSCARB2-mScarb2 chimeric mutants, we attempted to map the region that was important for efficient EV71 infection. L929 cells expressing chimeras that carried amino acids 142 to 204 from the human sequence were susceptible to EV71, while chimeras that carried the mouse sequence in this region were not. Moreover, this region was also critical for binding to virions. The determination of this region in hSCARB2 that is important for EV71 binding and infection greatly contributes to the understanding of virus-receptor interactions. Further studies will clarify the early steps of EV71 infection.We previously identified human scavenger receptor class B, member 2 (SCARB2), as a cellular receptor for enterovirus 71 (EV71). Expression of human SCARB2 (hSCARB2) permitted mouse L929 cells to efficiently bind to virions and to produce both viral proteins and progeny viruses upon EV71 infection. Mouse Scarb2 (mScarb2) exhibited 85.8% amino acid identity and 99.9% similarity to hSCARB2. The expression of mScarb2 in L929 cells conferred partial susceptibility. Very few virions bound to mScarb2-expressing cells. The viral titer in L929 cells expressing mScarb2 was approximately 40- to 100-fold lower than that in L929 cells expressing hSCARB2. Using hSCARB2-mScarb2 chimeric mutants, we attempted to map the region that was important for efficient EV71 infection. L929 cells expressing chimeras that carried amino acids 142 to 204 from the human sequence were susceptible to EV71, while chimeras that carried the mouse sequence in this region were not. Moreover, this region was also critical for binding to virions. The determination of this region in hSCARB2 that is important for EV71 binding and infection greatly contributes to the understanding of virus-receptor interactions. Further studies will clarify the early steps of EV71 infection. We previously identified human scavenger receptor class B, member 2 (SCARB2), as a cellular receptor for enterovirus 71 (EV71). Expression of human SCARB2 (hSCARB2) permitted mouse L929 cells to efficiently bind to virions and to produce both viral proteins and progeny viruses upon EV71 infection. Mouse Scarb2 (mScarb2) exhibited 85.8% amino acid identity and 99.9% similarity to hSCARB2. The expression of mScarb2 in L929 cells conferred partial susceptibility. Very few virions bound to mScarb2-expressing cells. The viral titer in L929 cells expressing mScarb2 was approximately 40- to 100-fold lower than that in L929 cells expressing hSCARB2. Using hSCARB2-mScarb2 chimeric mutants, we attempted to map the region that was important for efficient EV71 infection. L929 cells expressing chimeras that carried amino acids 142 to 204 from the human sequence were susceptible to EV71, while chimeras that carried the mouse sequence in this region were not. Moreover, this region was also critical for binding to virions. The determination of this region in hSCARB2 that is important for EV71 binding and infection greatly contributes to the understanding of virus-receptor interactions. Further studies will clarify the early steps of EV71 infection. |
| Author | Seiya Yamayoshi Satoshi Koike |
| Author_xml | – sequence: 1 givenname: Seiya surname: Yamayoshi fullname: Yamayoshi, Seiya organization: Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan – sequence: 2 givenname: Satoshi surname: Koike fullname: Koike, Satoshi organization: Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan |
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Mendeley... We previously identified human scavenger receptor class B, member 2 (SCARB2), as a cellular receptor for enterovirus 71 (EV71). Expression of human SCARB2... |
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| StartPage | 4937 |
| SubjectTerms | Amino Acid Sequence Animals Biological and medical sciences CD36 Antigens - genetics CD36 Antigens - metabolism Cell Line Enterovirus Enterovirus A, Human - physiology Fundamental and applied biological sciences. Psychology Humans Lysosomal Membrane Proteins - genetics Lysosomal Membrane Proteins - metabolism Mice Microbiology Miscellaneous Molecular Sequence Data Receptors, Scavenger - genetics Receptors, Scavenger - metabolism Receptors, Virus - genetics Receptors, Virus - metabolism Sequence Homology, Amino Acid Viral Load Virology Virus Attachment Virus-Cell Interactions |
| Title | Identification of a Human SCARB2 Region That Is Important for Enterovirus 71 Binding and Infection |
| URI | http://jvi.asm.org/content/85/10/4937.abstract https://www.ncbi.nlm.nih.gov/pubmed/21389126 https://www.proquest.com/docview/863426399 https://www.proquest.com/docview/888101349 https://pubmed.ncbi.nlm.nih.gov/PMC3126200 |
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