AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated

• Published in: Cancer letters Vol. 220; no. 2; pp. 211 - 220
• Main Authors: Jin, David K., Anderson, Eric C., Gilbert, Erin, Feuerman, Miriam H.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 08.04.2005; Elsevier Limited
• Subjects: Afr2; Alkylating Agents - pharmacology; Alpha-fetoprotein; alpha-Fetoproteins - biosynthesis; alpha-Fetoproteins - genetics; Animals; Binding sites; Carcinogens; Deoxyribonucleic acid; Diethylnitrosamine; Diethylnitrosamine - pharmacology; DNA; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene regulation; Laboratory animals; Liver regeneration; Liver Regeneration - genetics; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular weight; Rodents; Transgenes; Tumorigenesis; Tumors; Afr2; Diethylnitrosamine; Gene regulation; Liver regeneration; Alpha-fetoprotein

The level of alpha-fetoprotein (AFP) gene expression during liver regeneration in mice is regulated by the Afr2 gene. C3H/HeJ mice express 10-fold higher levels of AFP than C57BL/6J mice. We show that AFP gene expression is not Afr2 regulated after intoxication with the carcinogen diethylnitrosamine...