Prolactin promotes transepithelial migration of lymphocytes through CCL2

• Published in: Poultry science Vol. 104; no. 8; p. 105322
• Main Authors: Liu, Peng, Zuo, Jinjiao, Lu, Hui, Zhang, Bin, Wu, Caihong
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2025; Elsevier
• Subjects: Animals; CCL2; Cell Movement; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Co-culture model; Coculture Techniques - veterinary; Colostrum; Epithelial Cells - physiology; Estrogens - metabolism; Female; Mammary Glands, Animal - cytology; PHYSIOLOGY AND REPRODUCTION; Pregnancy; Prolactin; Prolactin - metabolism; Sus scrofa - physiology; T-Lymphocytes - physiology; Transepithelial migration; CCL2; Co-culture model; Prolactin; Transepithelial migration

The colostrum of sows contains a large number of lymphocytes originating from breast tissue. However, the mechanism of lymphocyte migration across the mammary epithelium remains unclear. Hormonal fluctuations during pregnancy are known to influence lymphocyte homing to the breast. In this study, we...