Fit for consumption: zebrafish as a model for tuberculosis

• Published in: Disease models & mechanisms Vol. 7; no. 7; pp. 777 - 784
• Main Authors: Cronan, Mark R, Tobin, David M
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.07.2014; The Company of Biologists Limited; The Company of Biologists
• Subjects: Animals; Bacteria; Disease models; Disease Models, Animal; Drug resistance; Genes; Genetics; Granulomas; Humans; Immune system; Immunity, Innate; Infections; Mortality; Mycobacterium; Mycobacterium marinum - physiology; Mycobacterium tuberculosis - physiology; Pathogenesis; Pathogens; Pathology; Review; Tuberculosis; Tuberculosis - immunology; Tuberculosis - microbiology; Tuberculosis - pathology; Vaccines; Zebrafish; Zebrafish - genetics; Zebrafish - microbiology; Mycobacterium; Genetics; Zebrafish; Tuberculosis; Disease models; Pathogenesis

Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has emerged as a useful model to investigate mycobacterial pathogenesis and treatment. Infection of zebrafish with Mycobacterium marinum, the cl...