Fit for consumption: zebrafish as a model for tuberculosis

Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has emerged as a useful model to investigate mycobacterial pathogenesis and treatment. Infection of zebrafish with Mycobacterium marinum, the cl...

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Published inDisease models & mechanisms Vol. 7; no. 7; pp. 777 - 784
Main Authors Cronan, Mark R, Tobin, David M
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 01.07.2014
The Company of Biologists Limited
The Company of Biologists
Subjects
Animals
Bacteria
Disease models
Disease Models, Animal
Drug resistance
Genes
Genetics
Granulomas
Humans
Immune system
Immunity, Innate
Infections
Mortality
Mycobacterium
Mycobacterium marinum - physiology
Mycobacterium tuberculosis - physiology
Pathogenesis
Pathogens
Pathology
Review
Tuberculosis
Tuberculosis - immunology
Tuberculosis - microbiology
Tuberculosis - pathology
Vaccines
Zebrafish
Zebrafish - genetics
Zebrafish - microbiology
Mycobacterium
Genetics
Zebrafish
Tuberculosis
Disease models
Pathogenesis
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Abstract Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has emerged as a useful model to investigate mycobacterial pathogenesis and treatment. Infection of zebrafish with Mycobacterium marinum, the closest relative of the Mycobacterium tuberculosis complex, recapitulates many aspects of human tuberculosis. The zebrafish model affords optical transparency, abundant genetic tools and in vivo imaging of the progression of infection. Here, we review how the zebrafish-M. marinum system has been deployed to make novel observations about the role of innate immunity, the tuberculous granuloma, and crucial host and bacterial genes. Finally, we assess how these findings relate to human disease and provide a framework for novel strategies to treat tuberculosis.
AbstractList Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has emerged as a useful model to investigate mycobacterial pathogenesis and treatment. Infection of zebrafish with Mycobacterium marinum, the closest relative of the Mycobacterium tuberculosis complex, recapitulates many aspects of human tuberculosis. The zebrafish model affords optical transparency, abundant genetic tools and in vivo imaging of the progression of infection. Here, we review how the zebrafish-M. marinum system has been deployed to make novel observations about the role of innate immunity, the tuberculous granuloma, and crucial host and bacterial genes. Finally, we assess how these findings relate to human disease and provide a framework for novel strategies to treat tuberculosis.
Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has emerged as a useful model to investigate mycobacterial pathogenesis and treatment. Infection of zebrafish with Mycobacterium marinum , the closest relative of the Mycobacterium tuberculosis complex, recapitulates many aspects of human tuberculosis. The zebrafish model affords optical transparency, abundant genetic tools and in vivo imaging of the progression of infection. Here, we review how the zebrafish– M. marinum system has been deployed to make novel observations about the role of innate immunity, the tuberculous granuloma, and crucial host and bacterial genes. Finally, we assess how these findings relate to human disease and provide a framework for novel strategies to treat tuberculosis.
Author Tobin, David M
Cronan, Mark R
AuthorAffiliation 2 Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
1 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
AuthorAffiliation_xml – name: 2 Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA
– name: 1 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Author_xml – sequence: 1
  givenname: Mark R
  surname: Cronan
  fullname: Cronan, Mark R
  organization: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
– sequence: 2
  givenname: David M
  surname: Tobin
  fullname: Tobin, David M
  email: david.tobin@duke.edu
  organization: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA. david.tobin@duke.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24973748$$D View this record in MEDLINE/PubMed
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Issue 7
Keywords Mycobacterium
Genetics
Zebrafish
Tuberculosis
Disease models
Pathogenesis
Language English
License 2014. Published by The Company of Biologists Ltd.
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Snippet Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has...
Despite efforts to generate new vaccines and antibiotics for tuberculosis, the disease remains a public health problem worldwide. The zebrafish Danio rerio has...
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SubjectTerms Animals
Bacteria
Disease models
Disease Models, Animal
Drug resistance
Genes
Genetics
Granulomas
Humans
Immune system
Immunity, Innate
Infections
Mortality
Mycobacterium
Mycobacterium marinum - physiology
Mycobacterium tuberculosis - physiology
Pathogenesis
Pathogens
Pathology
Review
Tuberculosis
Tuberculosis - immunology
Tuberculosis - microbiology
Tuberculosis - pathology
Vaccines
Zebrafish
Zebrafish - genetics
Zebrafish - microbiology
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Title Fit for consumption: zebrafish as a model for tuberculosis
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