A ventricular assist device powered by conditioned skeletal muscle
Background. We are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle. Methods. To evaluate the VAD hardware and to develop a muscle training regimen, 8 calves have been used in studies in which the right latissimus dorsi muscle was employed. Th...
Saved in:
Published in | The Annals of thoracic surgery Vol. 68; no. 2; pp. 780 - 784 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
New York, NY
Elsevier Inc
01.08.1999
Elsevier Science |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background. We are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle.
Methods. To evaluate the VAD hardware and to develop a muscle training regimen, 8 calves have been used in studies in which the right latissimus dorsi muscle was employed. The experiments were carried out to an approximately 4-month duration.
Results. There was significant conversion of type II (fast twitch) to type I (slow twitch) muscle fibers. This did not correlate well, however, with device performance. The device stroke volumes ranged from approximately 17 to 90 cc. This variability of outcome occurred despite the fact that identical hardware, surgical procedures, and training regimens were employed.
Conclusions. The results from the first eight studies lead us to speculate that perfusion may be important even when the muscle is working at pressures much lower than systemic blood pressure levels. In an attempt to augment tissue perfusion, we plan to investigate thermally induced angiogenesis as a possible mechanism for increasing blood flow to the tissue. |
---|---|
AbstractList | We are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle.
To evaluate the VAD hardware and to develop a muscle training regimen, 8 calves have been used in studies in which the right latissimus dorsi muscle was employed. The experiments were carried out to an approximately 4-month duration.
There was significant conversion of type II (fast twitch) to type I (slow twitch) muscle fibers. This did not correlate well, however, with device performance. The device stroke volumes ranged from approximately 17 to 90 cc. This variability of outcome occurred despite the fact that identical hardware, surgical procedures, and training regimens were employed.
The results from the first eight studies lead us to speculate that perfusion may be important even when the muscle is working at pressures much lower than systemic blood pressure levels. In an attempt to augment tissue perfusion, we plan to investigate thermally induced angiogenesis as a possible mechanism for increasing blood flow to the tissue. Background. We are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle. Methods. To evaluate the VAD hardware and to develop a muscle training regimen, 8 calves have been used in studies in which the right latissimus dorsi muscle was employed. The experiments were carried out to an approximately 4-month duration. Results. There was significant conversion of type II (fast twitch) to type I (slow twitch) muscle fibers. This did not correlate well, however, with device performance. The device stroke volumes ranged from approximately 17 to 90 cc. This variability of outcome occurred despite the fact that identical hardware, surgical procedures, and training regimens were employed. Conclusions. The results from the first eight studies lead us to speculate that perfusion may be important even when the muscle is working at pressures much lower than systemic blood pressure levels. In an attempt to augment tissue perfusion, we plan to investigate thermally induced angiogenesis as a possible mechanism for increasing blood flow to the tissue. BACKGROUNDWe are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle.METHODSTo evaluate the VAD hardware and to develop a muscle training regimen, 8 calves have been used in studies in which the right latissimus dorsi muscle was employed. The experiments were carried out to an approximately 4-month duration.RESULTSThere was significant conversion of type II (fast twitch) to type I (slow twitch) muscle fibers. This did not correlate well, however, with device performance. The device stroke volumes ranged from approximately 17 to 90 cc. This variability of outcome occurred despite the fact that identical hardware, surgical procedures, and training regimens were employed.CONCLUSIONSThe results from the first eight studies lead us to speculate that perfusion may be important even when the muscle is working at pressures much lower than systemic blood pressure levels. In an attempt to augment tissue perfusion, we plan to investigate thermally induced angiogenesis as a possible mechanism for increasing blood flow to the tissue. |
Author | Norman, John C Richards, Christopher L Burns, Gregory L Whalen, Robert L Olsen, Donald B Sherman, Craig W Bearnson, Gill B Lim, Gilbert W |
Author_xml | – sequence: 1 givenname: Robert L surname: Whalen fullname: Whalen, Robert L email: rlwhalen@ix.net organization: Whalen Biomedical Laboratories, Somerville, Massachusetts, USA – sequence: 2 givenname: Christopher L surname: Richards fullname: Richards, Christopher L organization: Whalen Biomedical Laboratories, Somerville, Massachusetts, USA – sequence: 3 givenname: Gilbert W surname: Lim fullname: Lim, Gilbert W organization: Whalen Biomedical Laboratories, Somerville, Massachusetts, USA – sequence: 4 givenname: Craig W surname: Sherman fullname: Sherman, Craig W organization: Whalen Biomedical Laboratories, Somerville, Massachusetts, USA – sequence: 5 givenname: John C surname: Norman fullname: Norman, John C organization: Whalen Biomedical Laboratories, Somerville, Massachusetts, USA – sequence: 6 givenname: Gill B surname: Bearnson fullname: Bearnson, Gill B organization: The University of Utah, Salt Lake City, Utah, USA – sequence: 7 givenname: Gregory L surname: Burns fullname: Burns, Gregory L organization: The University of Utah, Salt Lake City, Utah, USA – sequence: 8 givenname: Donald B surname: Olsen fullname: Olsen, Donald B organization: The University of Utah, Salt Lake City, Utah, USA |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1936724$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10475488$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkEtLxDAQgIMo7kN_gtKDiB6qSdMmm5Po4gsED-o5pJMpRLvtmrQr_nvjdlFvnoZhvnl9E7LdtA0ScsDoGaNMnD9RSnmaK1mcKHVKqWBFyrfImBVFloqsUNtk_IOMyCSE15hmsbxLRozmsshnszG5ukxW2HTeQV8bn5gQXOgSiysHmCzbD_Rok_IzgbaxrnPxBpuEN6yxM3Wy6APUuEd2KlMH3N_EKXm5uX6e36UPj7f388uHFHKZdSmApFbZitMyR6FozgEQUZYZArdyhhINZaaUpVFVJZgUxuaUc6iENCJ-MiXHw9ylb997DJ1euABY16bBtg9axv8koyqCxQCCb0PwWOmldwvjPzWj-lueXsvT32a0UnotT_PYd7hZ0JcLtH-6BlsRONoAJoCpK28acOGXU1zILI_YxYBhtLFy6HUAhw2gdR6h07Z1_1zyBZakjec |
CODEN | ATHSAK |
CitedBy_id | crossref_primary_10_1016_S0003_4975_03_00513_7 crossref_primary_10_1016_j_jss_2006_02_054 crossref_primary_10_1111_j_1525_1594_2006_00177_x crossref_primary_10_1152_jappl_2001_90_5_1977 |
Cites_doi | 10.1126/science.2951849 10.1161/01.CIR.89.3.1032 10.1016/S0140-6736(85)92329-3 |
ContentType | Journal Article Conference Proceeding |
Copyright | 1999 The Society of Thoracic Surgeons 1999 INIST-CNRS |
Copyright_xml | – notice: 1999 The Society of Thoracic Surgeons – notice: 1999 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/S0003-4975(99)00615-3 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1552-6259 |
EndPage | 784 |
ExternalDocumentID | 10_1016_S0003_4975_99_00615_3 10475488 1936724 S0003497599006153 |
Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
GrantInformation_xml | – fundername: Society of Thoracic Surgeons – fundername: NHLBI NIH HHS grantid: N01-HV-58158 |
GroupedDBID | --- --K .1- .55 .FO .GJ 0R~ 1B1 1P~ 1~5 23M 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M AAEDT AAEDW AAEJM AAIAV AALRI AAQFI AAQQT AAQXK AAXUO ABJNI ABLJU ABMAC ABOCM ACGFO ACGFS ACIUM ACRZS ADBBV ADMUD ADPAM AENEX AEVXI AFCTW AFFNX AFRHN AFTJW AGHFR AGZHU AHPSJ AI. AITUG AJJEV AJUYK ALMA_UNASSIGNED_HOLDINGS ALXNB AMRAJ ASPBG AVWKF AZFZN BAWUL BELOY C5W CS3 DIK E3Z EBS EFJIC EJD F5P FDB FEDTE FGOYB GBLVA GX1 HVGLF HZ~ IH2 IHE J1W J5H K-O KOM L7B M41 MO0 N9A NQ- O9- OA- OK1 OL. OVD P2P P6G PC. R2- RIG ROL RPZ SES SSZ TEORI TR2 UDS UNMZH UV1 VH1 W8F X7M XH2 XPP Z5R ZA5 ZGI ZXP 08R AAUGY IQODW AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c472t-cc70d9df30b4e69043cceee7b2ec3d78e7ea01ab7ba9ff6176ad4033cf67a6003 |
ISSN | 0003-4975 |
IngestDate | Sat Aug 17 01:44:37 EDT 2024 Fri Aug 23 01:11:18 EDT 2024 Sat Sep 28 08:40:04 EDT 2024 Sun Oct 29 17:09:13 EDT 2023 Fri Feb 23 02:29:25 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | Intensive cardiocirculatory care Cardiocirculatory support Calf Instrumentation therapy Ox Exploration Heart ventricle Latissimus dorsi muscle Instrumental stimulation Vertebrata Mammalia Animal Artiodactyla Hemodynamics Technique Ungulata |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MeetingName | International Conference on Circulatory Support Devices for Severe Cardiac Failure |
MergedId | FETCHMERGED-LOGICAL-c472t-cc70d9df30b4e69043cceee7b2ec3d78e7ea01ab7ba9ff6176ad4033cf67a6003 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | http://www.annalsthoracicsurgery.org/article/S0003497599006153/pdf |
PMID | 10475488 |
PQID | 70007109 |
PQPubID | 23479 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_70007109 crossref_primary_10_1016_S0003_4975_99_00615_3 pubmed_primary_10475488 pascalfrancis_primary_1936724 elsevier_sciencedirect_doi_10_1016_S0003_4975_99_00615_3 |
PublicationCentury | 1900 |
PublicationDate | 1999-08-01 |
PublicationDateYYYYMMDD | 1999-08-01 |
PublicationDate_xml | – month: 08 year: 1999 text: 1999-08-01 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | New York, NY |
PublicationPlace_xml | – name: New York, NY – name: Netherlands |
PublicationTitle | The Annals of thoracic surgery |
PublicationTitleAlternate | Ann Thorac Surg |
PublicationYear | 1999 |
Publisher | Elsevier Inc Elsevier Science |
Publisher_xml | – name: Elsevier Inc – name: Elsevier Science |
References | Patel, Lankford, Polidori, Pilla, Acker (BIB4) 1997; 7 Carrao, Chachques, Desnos, Hagege, Fontaliran, Carpentier (BIB6) 1996; 6 Greer, Stephenson (BIB5) 1997; 7 Carpentier, Chachques (BIB1) 1985; 1 Guldner, Eichstaedt, Klapproth (BIB3) 1994; 89 Acker, Hammond, Mannion, Salmons, Stephenson (BIB2) 1987; 236 Norman, Molokhia, Asimacoupoulous, Liss, Huffman (BIB7) 1971; 17 Carrao (10.1016/S0003-4975(99)00615-3_BIB6) 1996; 6 Patel (10.1016/S0003-4975(99)00615-3_BIB4) 1997; 7 Acker (10.1016/S0003-4975(99)00615-3_BIB2) 1987; 236 Carpentier (10.1016/S0003-4975(99)00615-3_BIB1) 1985; 1 Guldner (10.1016/S0003-4975(99)00615-3_BIB3) 1994; 89 Norman (10.1016/S0003-4975(99)00615-3_BIB7) 1971; 17 Greer (10.1016/S0003-4975(99)00615-3_BIB5) 1997; 7 |
References_xml | – volume: 89 start-page: 1032 year: 1994 end-page: 1040 ident: BIB3 article-title: Dynamic training of skeletal muscle ventricles. A method to increase muscular power for cardiac assistance publication-title: Circulation contributor: fullname: Klapproth – volume: 6 start-page: 333 year: 1996 end-page: 336 ident: BIB6 article-title: Eight-year human dynamic cardiomyoplasty publication-title: Basic Appl Myol contributor: fullname: Carpentier – volume: 236 start-page: 324 year: 1987 end-page: 327 ident: BIB2 article-title: Skeletal muscle as the potential power source for a cardiovascular pump publication-title: Science contributor: fullname: Stephenson – volume: 1 start-page: 1267 year: 1985 ident: BIB1 article-title: Myocardial substitution with a stimulated skeletal muscle publication-title: Lancet contributor: fullname: Chachques – volume: 7 start-page: 61 year: 1997 end-page: 65 ident: BIB5 article-title: Skeletal muscle ventricles publication-title: Basic Appl Myol contributor: fullname: Stephenson – volume: 17 start-page: 213 year: 1971 end-page: 218 ident: BIB7 article-title: Heat induced myocardial angiogenesis publication-title: Trans Am Soc Artif Organs contributor: fullname: Huffman – volume: 7 start-page: 5 year: 1997 end-page: 7 ident: BIB4 article-title: Dynamic cardiomyoplasty publication-title: Basic Appl Myol contributor: fullname: Acker – volume: 236 start-page: 324 year: 1987 ident: 10.1016/S0003-4975(99)00615-3_BIB2 article-title: Skeletal muscle as the potential power source for a cardiovascular pump publication-title: Science doi: 10.1126/science.2951849 contributor: fullname: Acker – volume: 89 start-page: 1032 year: 1994 ident: 10.1016/S0003-4975(99)00615-3_BIB3 article-title: Dynamic training of skeletal muscle ventricles. A method to increase muscular power for cardiac assistance publication-title: Circulation doi: 10.1161/01.CIR.89.3.1032 contributor: fullname: Guldner – volume: 6 start-page: 333 year: 1996 ident: 10.1016/S0003-4975(99)00615-3_BIB6 article-title: Eight-year human dynamic cardiomyoplasty publication-title: Basic Appl Myol contributor: fullname: Carrao – volume: 1 start-page: 1267 year: 1985 ident: 10.1016/S0003-4975(99)00615-3_BIB1 article-title: Myocardial substitution with a stimulated skeletal muscle publication-title: Lancet doi: 10.1016/S0140-6736(85)92329-3 contributor: fullname: Carpentier – volume: 7 start-page: 5 year: 1997 ident: 10.1016/S0003-4975(99)00615-3_BIB4 article-title: Dynamic cardiomyoplasty publication-title: Basic Appl Myol contributor: fullname: Patel – volume: 7 start-page: 61 year: 1997 ident: 10.1016/S0003-4975(99)00615-3_BIB5 article-title: Skeletal muscle ventricles publication-title: Basic Appl Myol contributor: fullname: Greer – volume: 17 start-page: 213 year: 1971 ident: 10.1016/S0003-4975(99)00615-3_BIB7 article-title: Heat induced myocardial angiogenesis publication-title: Trans Am Soc Artif Organs contributor: fullname: Norman |
SSID | ssj0002155 |
Score | 1.6430236 |
Snippet | Background. We are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle.
Methods. To evaluate the VAD... We are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle. To evaluate the VAD hardware and to develop a... BACKGROUNDWe are developing and testing a new ventricular assist device (VAD) to be powered by conditioned skeletal muscle.METHODSTo evaluate the VAD hardware... |
SourceID | proquest crossref pubmed pascalfrancis elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 780 |
SubjectTerms | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cattle Electric Stimulation Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Equipment Design Heart-Assist Devices Humans Intensive care medicine Medical sciences Muscle Contraction - physiology Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Stroke Volume |
Title | A ventricular assist device powered by conditioned skeletal muscle |
URI | https://dx.doi.org/10.1016/S0003-4975(99)00615-3 https://www.ncbi.nlm.nih.gov/pubmed/10475488 https://search.proquest.com/docview/70007109 |
Volume | 68 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaWckHiAKLAlhZyoBIoypK1ndg-LstCQLRCSyv2FvkVgRDbVZM9wJkfzjjOq7RVBZcoshJP5Pky_jye8SD0HAtjeTGVkRRER5RpGQkZJxHWseFG0IQSlyh8dJxmp_TDKlmNRr8HUUvbSk30ryvzSv5Hq9AGenVZsv-g2a5TaIB70C9cQcNwvazjq6calxjSnYFcfQWF6m86LAfJzm00cugiG2t3nzwPgTKDfl3KFBiKcONKpXkqCstj448vMmH5HeYklyz5Y1t26AL7nc0-LurogOUk7HzHy_fzbLZ8U0cCzgftYB1r3_sk7L052WJ5NDtunvzSOx78YQV86HjoMmIaI3TByhJXuc7vVtvGsCY4cmutoeVN-QBheGBGma_u1MzIzBeRu2Tsvd_hcyfu0C0eD7GoaVpE-hmu3dX_a-LrwhGBxKYM01voNiYicbbx3aoPFAJSlLR1F52YPg_sVS_7hRAvG7nXMZy7G1nCf1f4ginXr2hqZnNyD-32OZ_Bpw5i99HIrh-g17NggJrAoybwqAka1ATqZzBATdCiJvCo2UWnbxcn8yxqqm5EmjJcRVqz2AhTkFhRm4qYEg2iLVPYamIYt8zKeCoVU1IUBRDgVBoaE6KLlEmgz-Qh2lmDvMcoIEAEMFOxwTymlk4lV5xTJYHjyoIpMkaTdqTyjT9cJe-jDqGr3A1tLkReD20OL_B2PPOGIXrmlwMmbnr14ML49wK98sfoWauPHCys2zaTa3u2LXPmebgYo0deTYNvpQxW_Hzvhr6foDv9D7SPdqrzrT0ALluppzXU_gBenJfg |
link.rule.ids | 310,311,315,786,790,795,796,23958,23959,25170,27955,27956 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=proceeding&rft.title=The+Annals+of+thoracic+surgery&rft.atitle=A+ventricular+assist+device+powered+by+conditioned+skeletal+muscle&rft.au=WHALEN%2C+R.+L&rft.au=RICHARDS%2C+C.+L&rft.au=LIM%2C+G.+W&rft.au=SHERMAN%2C+C.+W&rft.date=1999-08-01&rft.pub=Elsevier+Science&rft.issn=0003-4975&rft.eissn=1552-6259&rft.volume=68&rft.issue=2&rft.spage=780&rft.epage=784&rft_id=info:doi/10.1016%2FS0003-4975%2899%2900615-3&rft.externalDBID=n%2Fa&rft.externalDocID=1936724 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-4975&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-4975&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-4975&client=summon |