Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression

• Published in: Psychopharmacology Vol. 233; no. 14; pp. 2813 - 2825
• Main Authors: du Jardin, Kristian Gaarn, Liebenberg, Nico, Müller, Heidi Kaastrup, Elfving, Betina, Sanchez, Connie, Wegener, Gregers
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2016; Springer; Springer Nature B.V
• Subjects: Animal research models; Animals; Anti-Anxiety Agents - therapeutic use; Antidepressants; Antidepressive Agents - pharmacology; Behavior, Animal - drug effects; Biomedical and Life Sciences; Biomedicine; Comparative analysis; Depression (Mood disorder); Depressive Disorder - drug therapy; Disease Models, Animal; Dosage and administration; Drug therapy; Fluoxetine; Fluoxetine - pharmacology; Ketamine; Ketamine - pharmacology; Locomotion - drug effects; Male; Memory Disorders - drug therapy; Mental depression; Neurosciences; Original Investigation; Patient outcomes; Pharmacology/Toxicology; Piperazines - pharmacology; Psychiatry; Rats; Recognition (Psychology) - drug effects; Serotonin; Serotonin Uptake Inhibitors - therapeutic use; Sulfides - pharmacology; Swimming; Vortioxetine; Ketamine; Forced swim test; Serotonin; Fluoxetine; Antidepressants; Object recognition; Vortioxetine

Rationale The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. Vortioxetine is a multimodal-acting antidepressant that is hypothesized to exe...