Adhesins of Yeasts: Protein Structure and Interactions

The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces...

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Published inJournal of fungi (Basel) Vol. 4; no. 4; p. 119
Main Author Willaert, Ronnie G
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.10.2018
MDPI
Subjects
Adhesins
Als proteins
Amino acid sequence
Candida albicans
Candida glabrata
Candidiasis
Carbohydrates
Cell adhesion & migration
Cell walls
Epa proteins
Flo proteins
Flocculation
Fungal infections
Glycoproteins
Lectins
Nutrients
Protein families
Protein structure
Proteins
Review
Saccharomyces cerevisiae
Self-recognition
the agglutinin-like sequence protein family
the epithelial adhesion family
the flocculation protein family
Yeast
yeast adhesions
Als proteins
Candida albicans
the epithelial adhesion family
the agglutinin-like sequence protein family
yeast adhesions
the flocculation protein family
Candida glabrata
Epa proteins
Flo proteins
Saccharomyces cerevisiae
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Abstract The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces. Infectious yeast diseases such as candidiasis are initiated by the adhesion of the yeast cells to host cells. Adhesion is accomplished by adhesin proteins that are attached to the cell wall and stick out to interact with other cells or substrates. Protein structures give detailed insights into the molecular mechanism of adhesin-ligand interaction. Currently, only the structures of a very limited number of N-terminal adhesion domains of adhesins have been solved. Therefore, this review focuses on these adhesin protein families. The protein architectures, protein structures, and ligand interactions of the flocculation protein family of ; the epithelial adhesion family of ; and the agglutinin-like sequence protein family of are reviewed and discussed.
AbstractList The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast Saccharomyces cerevisiae can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces. Infectious yeast diseases such as candidiasis are initiated by the adhesion of the yeast cells to host cells. Adhesion is accomplished by adhesin proteins that are attached to the cell wall and stick out to interact with other cells or substrates. Protein structures give detailed insights into the molecular mechanism of adhesin-ligand interaction. Currently, only the structures of a very limited number of N-terminal adhesion domains of adhesins have been solved. Therefore, this review focuses on these adhesin protein families. The protein architectures, protein structures, and ligand interactions of the flocculation protein family of S. cerevisiae; the epithelial adhesion family of C. glabrata; and the agglutinin-like sequence protein family of C. albicans are reviewed and discussed.
The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces. Infectious yeast diseases such as candidiasis are initiated by the adhesion of the yeast cells to host cells. Adhesion is accomplished by adhesin proteins that are attached to the cell wall and stick out to interact with other cells or substrates. Protein structures give detailed insights into the molecular mechanism of adhesin-ligand interaction. Currently, only the structures of a very limited number of N-terminal adhesion domains of adhesins have been solved. Therefore, this review focuses on these adhesin protein families. The protein architectures, protein structures, and ligand interactions of the flocculation protein family of ; the epithelial adhesion family of ; and the agglutinin-like sequence protein family of are reviewed and discussed.
The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast Saccharomyces cerevisiae can switch from a unicellular lifestyle to a multicellular one. A crucial step in multicellular lifestyle adaptation is self-recognition, self-interaction, and adhesion to abiotic surfaces. Infectious yeast diseases such as candidiasis are initiated by the adhesion of the yeast cells to host cells. Adhesion is accomplished by adhesin proteins that are attached to the cell wall and stick out to interact with other cells or substrates. Protein structures give detailed insights into the molecular mechanism of adhesin-ligand interaction. Currently, only the structures of a very limited number of N-terminal adhesion domains of adhesins have been solved. Therefore, this review focuses on these adhesin protein families. The protein architectures, protein structures, and ligand interactions of the flocculation protein family of S. cerevisiae ; the epithelial adhesion family of C. glabrata ; and the agglutinin-like sequence protein family of C. albicans are reviewed and discussed.
Author Willaert, Ronnie G
AuthorAffiliation 2 Department Bioscience Engineering, University Antwerp, 2020 Antwerp, Belgium
1 Alliance Research Group VUB-UGent NanoMicrobiology (NAMI), IJRG VUB-EPFL NanoBiotechnology & NanoMedicine (NANO), Research Group Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Ronnie.Willaert@vub.be or Ronnie.Willaert@uantwerpen.be ; Tel.: +32-26291846
AuthorAffiliation_xml – name: 1 Alliance Research Group VUB-UGent NanoMicrobiology (NAMI), IJRG VUB-EPFL NanoBiotechnology & NanoMedicine (NANO), Research Group Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Ronnie.Willaert@vub.be or Ronnie.Willaert@uantwerpen.be ; Tel.: +32-26291846
– name: 2 Department Bioscience Engineering, University Antwerp, 2020 Antwerp, Belgium
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  surname: Willaert
  fullname: Willaert, Ronnie G
  email: Ronnie.Willaert@vub.be, Ronnie.Willaert@vub.be
  organization: Department Bioscience Engineering, University Antwerp, 2020 Antwerp, Belgium. Ronnie.Willaert@vub.be
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30373267$$D View this record in MEDLINE/PubMed
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2018 by the authors. 2018
Copyright_xml – notice: 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 4
Keywords Als proteins
Candida albicans
the epithelial adhesion family
the agglutinin-like sequence protein family
yeast adhesions
the flocculation protein family
Candida glabrata
Epa proteins
Flo proteins
Saccharomyces cerevisiae
Language English
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Snippet The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast can switch from a unicellular lifestyle to a...
The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast Saccharomyces cerevisiae can switch from a...
The ability of yeast cells to adhere to other cells or substrates is crucial for many yeasts. The budding yeast Saccharomyces cerevisiae can switch from a...
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SubjectTerms Adhesins
Als proteins
Amino acid sequence
Candida albicans
Candida glabrata
Candidiasis
Carbohydrates
Cell adhesion & migration
Cell walls
Epa proteins
Flo proteins
Flocculation
Fungal infections
Glycoproteins
Lectins
Nutrients
Protein families
Protein structure
Proteins
Review
Saccharomyces cerevisiae
Self-recognition
the agglutinin-like sequence protein family
the epithelial adhesion family
the flocculation protein family
Yeast
yeast adhesions
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Title Adhesins of Yeasts: Protein Structure and Interactions
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