Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

• Published in: Nutrients Vol. 12; no. 3; p. 679
• Main Authors: Abd Wahab, Nurul Azwa, Lajis, Nordin H, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.03.2020; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Androgen receptors; androgen-dependent prostate cancer; androgen-independent prostate cancer; Androgens; Androgens - metabolism; Apoptosis; Bcl-2 protein; Biopsy; Biosynthesis; Cancer therapies; Cell growth; Cell proliferation; Clinical trials; Clinical Trials as Topic; Curcumin; Curcumin - therapeutic use; Cyclin D1; Depletion; Drugs; Gene amplification; Gene expression; Genotype & phenotype; Health services; Humans; Kinases; Life expectancy; Lifestyles; Ligands; Lymphocytes B; Lymphoma; Male; MicroRNAs - metabolism; miRNA; molecular mechanism; Mortality; Mutation; Natural products; Neoplasm Proteins - metabolism; NF-κB protein; Phosphatase; Phosphatidylinositol; Prostate cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; Protein-serine/threonine kinase; Radiation therapy; Review; RNA, Neoplasm - metabolism; Signal transduction; TOR protein; Transcription factors; Vitamins; Wnt protein; Wnt Signaling Pathway - drug effects; United States > US; molecular mechanism; prostate cancer; androgen-independent prostate cancer; androgen-dependent prostate cancer; curcumin

Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden of PCa keeps rising regardless of the emerging cutting-edge technologies for treatment and drug designation. There are a number of treatment options...