GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during Disease

• Published in: Journal of clinical medicine Vol. 9; no. 2; p. 456
• Main Authors: Duarte Azevedo, Marcelo, Sander, Sibilla, Tenenbaum, Liliane
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.02.2020; MDPI
• Subjects: Clinical medicine; Dopamine; Heparan sulfate; Nervous system; Neurons; Parkinson's disease; Review; Rodents; Spinal cord; rearranged during transfection; neuroinflammation; glial-cell-line-derived neurotrophic factor; gene therapy; GDNF family receptor alpha 1; astrocyte; microglia; Parkinson’s disease

In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex with the GDNF family recepto...