Metal-organic frameworks (MOFs) as host materials for the enhanced delivery of biomacromolecular therapeutics

• Published in: Chemical communications (Cambridge, England) Vol. 57; no. 91; pp. 1298 - 1211
• Main Authors: Tong, Pei-Hong, Zhu, Ling, Zang, Yi, Li, Jia, He, Xiao-Peng, James, Tony D
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 16.11.2021
• Subjects: Antibodies; Antigens; Biocompatibility; Biomedical materials; Chemical compounds; DNA; Drug Delivery Systems; Encapsulation; Gene therapy; Health services; humans; immunotherapy; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Oxidation; Pharmaceutical Preparations - chemistry; Pharmacology; Polypeptides; Polysaccharides; Pore size; porosity; RNA; starvation; Supramolecular compounds

Biomacromolecular drugs have become an important class of therapeutic agents for the treatment of human diseases. Considering their high propensity for being degraded in the human body, the choice of an appropriate delivery system is key to ensure the therapeutic efficacy of biomacromolecular drugs...