Circulating and tissue endothelin immunoreactivity in hypercholesterolemic pigs

• Published in: Circulation (New York, N.Y.) Vol. 88; no. 6; pp. 2923 - 2928
• Main Authors: LERMAN, A, WEBSTER, M. W. I, CHESEBRO, J. H, EDWARDS, W. D, CHI-MING WEI, FUSTER, V, BURNETT, J. C
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.1993
• Subjects: Acetylcholine - pharmacology; Animals; Arteriosclerosis - etiology; Biological and medical sciences; Cholesterol, Dietary - administration & dosage; Coronary Vessels - drug effects; Coronary Vessels - physiopathology; Disorders of blood lipids. Hyperlipoproteinemia; Endothelins - blood; Endothelins - metabolism; Hypercholesterolemia - blood; Hypercholesterolemia - etiology; Hypercholesterolemia - physiopathology; Immunohistochemistry; Male; Medical sciences; Metabolic diseases; Swine; Swine, Miniature; Vasoconstriction - drug effects; Vasoconstriction - physiology; Immunohistochemistry; Endothelin; Hypercholesterolemia; Animal; Coronary artery; Vasoconstriction; Metabolic diseases; Exploration; Endothelium derived relaxing factor; Cholesterol; Blood plasma

Hypercholesterolemia is characterized by a coronary vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine. This abnormality may be due to reduced synthesis of endothelium-derived relaxing factor and/or enhanced synthesis and release of an endothelium-derived contracting fa...