Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

• Published in: Disease models & mechanisms Vol. 14; no. 11
• Main Authors: Dhondt, Ineke, Verschuuren, Clara, Zečić, Aleksandra, Loier, Tim, Braeckman, Bart P, De Vos, Winnok H
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.11.2021; The Company of Biologists
• Subjects: Age; ageing; Aging; Aging - physiology; Animals; Automation; Biomarkers; c. elegans; C. Elegans as a Disease Model; Caenorhabditis elegans - genetics; Caenorhabditis elegans Proteins - genetics; Genotype & phenotype; healthspan; Humans; image analysis; Longevity - genetics; Morphology; Muscles; Nematodes; phenotype prediction; Sarcopenia; Trends; Sarcopenia; C. elegans; Image analysis; Healthspan; Phenotype prediction; Ageing

Sarcopenia encompasses a progressive decline in muscle quantity and quality. Given its close association with ageing, it may represent a valuable healthspan marker. The commonalities with human muscle structure and facile visualization possibilities make Caenorhabditis elegans an attractive model fo...