PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts

• Published in: Journal of cell science Vol. 131; no. 13; p. jcs213579
• Main Authors: Nardi, Francesca, Fitchev, Philip, Franco, Omar E, Ivanisevic, Jelena, Scheibler, Adrian, Hayward, Simon W, Brendler, Charles B, Welte, Michael A, Crawford, Susan E
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.07.2018
• Subjects: Adaptations; Amplification; Cancer; Cell cycle; Centrosomes; Epithelium; Fibroblasts; Lipase; Lipid metabolism; Lipids; Lipogenesis; Metabolism; Phenotypes; Pigment epithelium-derived factor; Plastic properties; Plasticity; Programming; Prostate cancer; Proteins; Regulators; Restoration; Triglycerides; Tumors; ATGL (PNPLA2); β-catenin; CAF; PEDF (SERPINF); Centrosome; MTOC

Prostate tumors make metabolic adaptations to ensure adequate energy and amplify cell cycle regulators, such as centrosomes, to sustain their proliferative capacity. It is not known whether cancer-associated fibroblasts (CAFs) undergo metabolic re-programming. We postulated that CAFs augment lipid s...