A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights

Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pha...

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Published inMarine drugs Vol. 20; no. 5; p. 279
Main Authors Mohibbullah, Md, Haque, Md. Nazmul, Sohag, Abdullah Al Mamun, Hossain, Md. Tahmeed, Zahan, Md. Sarwar, Uddin, Md. Jamal, Hannan, Md. Abdul, Moon, Il Soo, Choi, Jae-Suk
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.04.2022
MDPI
Subjects
Algae
Anticancer properties
Antioxidants
Antitumor agents
bioactivities
Biocompatibility
Cancer
Carotenoids
Chemical kinetics
Diabetes mellitus
Diatoms
Disease prevention
Fucoxanthin
Functional foods & nutraceuticals
Heart diseases
Herbal medicine
Human subjects
Humans
in vitro
in vivo
Inflammation
Marine microorganisms
Metabolism
Metabolites
Microorganisms
Molecular modelling
Neoplasms
Nervous system
Obesity
Oxidative stress
Pharmaceuticals
Pharmacokinetics
Pharmacology
Review
safety and toxicity
Scientific papers
Seaweed - chemistry
Skin diseases
Toxicity
Tumors
Xanthophylls
Xanthophylls - chemistry
Xanthophylls - pharmacology
Xanthophylls - therapeutic use
pharmacokinetics
safety and toxicity
in vivo
fucoxanthin
in vitro
bioactivities
Online AccessGet full text
ISSN1660-3397
1660-3397
DOI10.3390/md20050279

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Abstract Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.
AbstractList Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.
Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.
Author Mohibbullah, Md
Uddin, Md. Jamal
Choi, Jae-Suk
Hossain, Md. Tahmeed
Hannan, Md. Abdul
Zahan, Md. Sarwar
Moon, Il Soo
Haque, Md. Nazmul
Sohag, Abdullah Al Mamun
AuthorAffiliation 2 Seafood Research Center, Silla University, #605, Advanced Seafood Processing Complex, Wonyang-ro, Amnam-dong, Seo-gu, Busan 49277, Korea
1 Department of Fishing and Post Harvest Technology, Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh; mmohib.fpht@sau.edu.bd
5 Department of Fisheries Biology and Genetics, Patuakhali Science and Technology University, Patuakhali 8602, Bangladesh
7 ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh; mszahan@hotmail.com (M.S.Z.); hasan800920@gmail.com (M.J.U.)
4 Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 38066, Korea; habib.332@gmail.com (M.N.H.); moonis@dongguk.ac.kr (I.S.M.)
6 Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh; sohag2010bmb.sust@gmail.com (A.A.M.S.); tahmeed.hossain@bau.edu.bd (M.T.H.); hannanbmb@bau.edu.bd (M.A.H.)
3 Department of Food Biotechnology, Division of Bioindustry, College of Medical and L
AuthorAffiliation_xml – name: 7 ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh; mszahan@hotmail.com (M.S.Z.); hasan800920@gmail.com (M.J.U.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35621930$$D View this record in MEDLINE/PubMed
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Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 5
Keywords pharmacokinetics
safety and toxicity
in vivo
fucoxanthin
in vitro
bioactivities
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Snippet Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It...
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StartPage 279
SubjectTerms Algae
Anticancer properties
Antioxidants
Antitumor agents
bioactivities
Biocompatibility
Cancer
Carotenoids
Chemical kinetics
Diabetes mellitus
Diatoms
Disease prevention
Fucoxanthin
Functional foods & nutraceuticals
Heart diseases
Herbal medicine
Human subjects
Humans
in vitro
in vivo
Inflammation
Marine microorganisms
Metabolism
Metabolites
Microorganisms
Molecular modelling
Neoplasms
Nervous system
Obesity
Oxidative stress
Pharmaceuticals
Pharmacokinetics
Pharmacology
Review
safety and toxicity
Scientific papers
Seaweed - chemistry
Skin diseases
Toxicity
Tumors
Xanthophylls
Xanthophylls - chemistry
Xanthophylls - pharmacology
Xanthophylls - therapeutic use
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Title A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights
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