ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM

• Published in: Theranostics Vol. 11; no. 12; pp. 5926 - 5938
• Main Authors: Zhou, Yanming, Lin, Furong, Wan, Tao, Chen, Ai, Wang, Huihui, Jiang, Bin, Zhao, Wentao, Liao, Shan, Wang, Shijie, Li, Guannan, Xu, Zhenzhen, Wang, Jinyang, Zhang, Jia, Ma, Huanhuan, Lin, Donghai, Li, Qinxi
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2021; Ivyspring International Publisher
• Subjects: Cell culture; Enzymes; Glucose; Kinases; Liver cancer; Metastasis; Pancreatic cancer; Plasmids; Proteins; Research Paper; Tumorigenesis; China; intrahepatic metastasis; ZEB1; non-classic binding; PFKM; glycolysis

Metabolic reprogramming, especially Warburg effect, is a key event in tumor initiation and progression. ZEB1 plays a vital role in metastasis of various cancers. We previously found that ZEB1 was excessively expressed in hepatocellular carcinoma (HCC) and its high expression was closely correlated w...