Identification of Cyclic Sulfonamides with an N- Arylacetamide Group as α-Glucosidase and α-Amylase Inhibitors: Biological Evaluation and Molecular Modeling

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 1; p. 106
• Main Authors: Saddique, Furqan Ahmad, Ahmad, Matloob, Ashfaq, Usman Ali, Muddassar, Muhammad, Sultan, Sadia, Zaki, Magdi E A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.01.2022; MDPI
• Subjects: 1,2-benzothiazine; acetamide; Arthritis; Carbohydrates; Diabetes; Enzymes; Glucose; Hydrogen bonds; Hyperglycemia; Insulin resistance; Ligands; molecular modeling; Severe acute respiratory syndrome coronavirus 2; synthesis; α-amylase; α-glucosidase; synthesis; α-glucosidase; α-amylase; 1,2-benzothiazine; molecular modeling; anti-diabetic; acetamide

Diabetes mellitus (DM), a complicated metabolic disorder, is due to insensitivity to insulin function or reduction in insulin secretion, which results in postprandial hyperglycemia. α-Glucosidase inhibitors (AGIs) and α-amylase inhibitors (AAIs) block the function of digestive enzymes, which delays...