OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance

• Published in: Biomaterials Vol. 284; p. 121523
• Main Authors: Hou, Da-Yong, Xiao, Wu-Yi, Wang, Jia-Qi, Yaseen, Muhammad, Wang, Zhi-Jia, Fei, Yue, Wang, Man-Di, Wang, Lu, Wang, Hui, Shi, Xinghua, Cai, Meng-meng, Feng, Hai-Tao, Xu, Wanhai, Li, Li-Li
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2022
• Subjects: biocompatible materials; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; breasts; cell proliferation; drug therapy; glucose; Glycolysis; Glycopeptide; glycopeptides; Glycopeptides - metabolism; Humans; Male; metabolites; metastasis; muscles; Muscles - metabolism; Nano-activator; PKM2; Protein Isoforms - metabolism; pyruvate kinase; Pyruvate Kinase - metabolism; serine; Switching catabolic pathways; Glycolysis; Nano-activator; Glycopeptide; PKM2; Switching catabolic pathways

Tumor cells intensively engage in metabolic reprogramming for enhancing the availability of glycolytic metabolites and support cell proliferation. As the most important rate-limiting enzyme in aerobic glycolysis, activating the pyruvate kinase muscle isoform 2 (PKM2) from dimers to tetramers has bec...