Myocardial Dysfunction after Severe Food Restriction Is Linked to Changes in the Calcium-Handling Properties in Rats

• Published in: Nutrients Vol. 11; no. 9; p. 1985
• Main Authors: Deus, Adriana Fernandes de, Silva, Vítor Loureiro da, de Souza, Sérgio Luiz Borges, Mota, Gustavo Augusto Ferreira, Sant'Ana, Paula Grippa, Vileigas, Danielle Fernandes, Lima-Leopoldo, Ana Paula, Leopoldo, André Soares, Campos, Dijon Henrique Salomé de, de Tomasi, Loreta Casquel, Padovani, Carlos Roberto, Kolwicz, Jr, Stephen C, Cicogna, Antonio Carlos
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.08.2019; MDPI
• Subjects: Adaptation; Adiposity; Animals; Body fat; Ca2+-transporting ATPase; Calcium; Calcium (reticular); Calcium - metabolism; Calcium channels (L-type); Calcium Channels, L-Type - metabolism; Calcium ions; Calcium Signaling; calcium transient proteins; Caloric Restriction; Calsequestrin; Cardiac function; Cardiac muscle; Contraction; Correlation analysis; Disease Models, Animal; Exercise; Fluorides; Food; Food availability; Food intake; Handling; Heart Diseases - etiology; Heart Diseases - metabolism; Heart Diseases - pathology; Heart Diseases - physiopathology; Heart failure; Heart function; heart impairment; L-type calcium channel; Laboratory animals; Male; Malnutrition; Malnutrition - complications; Malnutrition - metabolism; Malnutrition - pathology; Malnutrition - physiopathology; Mitochondria, Heart - metabolism; Mitochondria, Heart - pathology; Myocardial Contraction; Myocardium; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Na+/Ca2+ exchanger; papillary muscle assay; Papillary Muscles - metabolism; Papillary Muscles - pathology; Papillary Muscles - physiopathology; Phospholamban; Protein expression; Proteins; Rats, Inbred WKY; Ryanodine receptors; Sarcoplasmic reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; SERCA2a; Weight Loss; Brazil; United States > US; malnutrition; papillary muscle assay; SERCA2a; L-type calcium channel; calcium transient proteins; heart impairment

Severe food restriction (FR) impairs cardiac performance, although the causative mechanisms remain elusive. Since proteins associated with calcium handling may contribute to cardiac dysfunction, this study aimed to evaluate whether severe FR results in alterations in the expression and activity of C...