The Microbiota: A New Variable Impacting Cancer Treatment Outcomes

Preclinical evidence has established that the host commensal microbiota can contribute to therapeutic response in cancer models, a finding supported by early clinical data. This connection between the microbiome and clinical outcome in oncology is cause for new consideration in the administration of...

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Bibliographic Details
Published inClinical cancer research Vol. 23; no. 13; pp. 3229 - 3231
Main Authors Fessler, Jessica L, Gajewski, Thomas F
Format Journal Article
LanguageEnglish
Published United States American Association for Cancer Research Inc 01.07.2017
Subjects
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Antibiotics
Cancer
Cancer therapies
Humans
Microbiomes
Microbiota
Microbiota - drug effects
Neoplasms - drug therapy
Neoplasms - microbiology
Treatment Outcome
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Summary:Preclinical evidence has established that the host commensal microbiota can contribute to therapeutic response in cancer models, a finding supported by early clinical data. This connection between the microbiome and clinical outcome in oncology is cause for new consideration in the administration of antibiotics and microbiota-modulating interventions to improve outcomes. .
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-17-0864