A Neutrality Test for Detecting Selection on DNA Methylation Using Single Methylation Polymorphism Frequency Spectrum

• Published in: Genome biology and evolution Vol. 7; no. 1; pp. 154 - 171
• Main Authors: Wang, Jun, Fan, Chuanzhu
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2015
• Subjects: Computer Simulation; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; Epigenesis, Genetic; Epigenetics; Genetic Drift; Genetic Variation; Genomes; Humans; Mutation; Neutrality; Selection, Genetic - genetics; epimutation; site frequency; Tajima’s D; single methylation polymorphism; epigenetics; neutrality test

Inheritable epigenetic mutations (epimutations) can contribute to transmittable phenotypic variation. Thus, epimutations can be subject to natural selection and impact the fitness and evolution of organisms. Based on the framework of the modified Tajima's D test for DNA mutations, we developed...