HNPCC-associated small bowel cancer: clinical and molecular characteristics

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 128; no. 3; p. 590
• Main Authors: Schulmann, Karsten, Brasch, Frank E, Kunstmann, Erdmute, Engel, Christoph, Pagenstecher, Constanze, Vogelsang, Holger, Krüger, Stefan, Vogel, Tilman, Knaebel, Hanns-Peter, Rüschoff, Josef, Hahn, Stephan A, Knebel-Doeberitz, Magnus V, Moeslein, Gabriela, Meltzer, Stephen J, Schackert, Hans K, Tympner, Christiane, Mangold, Elisabeth, Schmiegel, Wolff
• Format: Journal Article
• Language: English
• Published: United States 01.03.2005
• Subjects: Adolescent; Adult; Aged; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism; Colorectal Neoplasms, Hereditary Nonpolyposis - mortality; Colorectal Neoplasms, Hereditary Nonpolyposis - pathology; Duodenal Neoplasms - genetics; Duodenal Neoplasms - pathology; Female; Frameshift Mutation; Germ-Line Mutation; Humans; Immunohistochemistry; Intestinal Neoplasms - genetics; Intestinal Neoplasms - metabolism; Intestinal Neoplasms - mortality; Intestinal Neoplasms - pathology; Intestine, Small - pathology; Male; Microsatellite Repeats; Middle Aged

The risk for small bowel cancer (SBC) is significantly increased in hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC-associated SBCs are poorly characterized. Thirty-two SBCs were characterized according to clinical, pathologic, and germline mutation data. Histomorphologic characteristics, m...