Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin

• Published in: Theranostics Vol. 11; no. 13; pp. 6461 - 6476
• Main Authors: Li, Qingyang, Zhu, Zhenlai, Wang, Lei, Lin, Yiting, Fang, Hui, Lei, Jie, Cao, Tianyu, Wang, Gang, Dang, Erle
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2021; Ivyspring International Publisher
• Subjects: Angiogenesis; Blood vessels; Cell adhesion & migration; Cytokines; Gene expression; Genomics; Metabolism; Neutrophils; Physiology; Research Paper; Skin diseases; single-cell RNA sequencing; metabolic diversity; skin vessel heterogeneity; vascular endothelial cells; skin arteriovenous markers

Vascular endothelial cells (ECs) are increasingly recognized as active players in intercellular crosstalk more than passive linings of a conduit for nutrition delivery. Yet, their functional roles and heterogeneity in skin remain uncharacterized. We have used single-cell RNA sequencing (scRNA-seq) a...